pH/葡萄糖双重响应含苯硼酸两亲嵌段共聚物的RAFT合成及自组装行为  

Direct RAFT Polymerization and Self-assemble Behaviour of pH/Glucose Dual-responsive Phenylboronic Acid Block Copolymers

作　　者：阳彩霞 孙芬 梁焱 王国祥[1] 梁恩湘[1] 周宁波[1] YANG Cai-xia;SUN Fen;LIANG Yan;WANG Guo-xiang;LIANG En-xiang;ZHOU Ning-bo(College of Chemistry and Chemical Engineering,Hunan Institute of Science and Technology,Yueyang 414006,China;Nanhu College,Hunan Institute of Science and Technology,Yueyang 414006,China)

机构地区：[1]湖南理工学院化学化工学院,湖南岳阳414006 [2]湖南理工学院南湖学院,湖南岳阳414006

出　　处：《合成化学》2019年第8期612-616,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(51503063,51674117,21471053,51873059);湖南省自然科学基金资助项目(2018JJ3211)

摘　　要：采用可逆加成-断裂链转移聚合法(RAFT)制得PNIPAM-macroCTA大分子引发剂(2);2与苯硼酸(PBA)衍生物单体(3)直接共聚合成了含苯硼酸的嵌段共聚物PNIPAM-b-PPBA(4),其结构经1 H NMR和GPC确证。采用1 H NMR和动态光散射(DLS)对4在溶液中的自组装行为进行了研究。结果表明:4具有pH和糖双重响应性,可形成以PPBA为核,PNIPAM为壳的胶束。A macromolecular chain transfer agent PNIPAM-macroCTA(2)was synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization.2 was copolymerized with phenylboronic acid derivative monomer(3)to obtain copolymer PNIPAM-b-PPBA(4).The structures were confirmed by 1 H NMR and GPC.The self-assemble behavior of 4 in solution was further investigated by 1 H NMR and dynamic light scattering(DLS).The results showed that 4 consisting of PPBA cores and PNIPAM coronas could exhibit double-responsiveness to pH and glucose.

关 键 词：苯硼酸嵌段共聚物 可逆加成-断裂链转移聚合 合成 自组装 双重响应 

分 类 号：TQ31[化学工程—高聚物工业] O63[理学—高分子化学]