新型3-烷氧基-四取代氧化吲哚的无催化剂无溶剂合成  

Catalyst-and Solvent-free Synthesis of Novel 3-Alkoxylated Tetrasubstituted Oxindoles

作　　者：王关炼 汪军鑫 杨楷模 刘雄利[1] 邓国栋[1] WANG Guan-lian;WANG Jun-xin;YANG Kai-mo;LIU Xiong-li;DENG Guo-dong(Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,School of pharmacy,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学药学院贵州省药食同源植物资源开发工程技术研究中心

出　　处：《合成化学》2019年第8期627-632,共6页Chinese Journal of Synthetic Chemistry

基　　金：贵州省科技项目(黔科合J字[2009]2321号)

摘　　要：以3-氯氧化吲哚和甲醇(或甘油)为原料,在无催化剂无溶剂条件下经SN1反应合成了10个新型的3-甲氧基-四取代氧化吲哚(产率36%~93%)和10个新型的3-甘油拼接四取代氧化吲哚(产率71%~87%),其结构经1H NMR,13 C NMR和HR-MS(ESI-TOF)表征。Using 3-halogenated oxindoles and methanol(or glycerol)as starting materials,ten novel 3-methoxylated tetrasubstituted oxindoles(yields of 36%~93%)and ten novel 3-glycerol-fused tetrasubstituted oxindoles(yields of 71%~87%)were synthesized via S N 1 reaction,respectively.The structures were characterized by 1 H NMR,13 C NMR and HR-MS(ESI-TOF).

关 键 词：3-氯氧化吲哚 绿色合成 SN1反应 3-烷氧基-四取代氧化吲哚 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]