一种合成马来内酰胺衍生物的新方法  

A New Method for The Synthesis of Maleimide Derivatives

作　　者：陈欢[1,2] 余瑜 周静[1] CHEN Huan;YU Yu;ZHOU Jing(College of Pharmaceutical Sciences,Chongqing Medical University,Chongqing 400016,China;Department of Pharmacy,Suining First People’s Hospital,Suining 629000,China)

机构地区：[1]重庆医科大学药学院,重庆400016 [2]遂宁市第一人民医院药剂科,四川遂宁629000

出　　处：《合成化学》2019年第8期666-668,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(81172097,30371632)

摘　　要：报道了一种合成马来酰亚胺衍生物的新方法。以顺丁烯二酸酐为起始原料,经开环酰胺化、脱水关环两步反应合成了15个目标化合物,其结构经1H NMR确证。A new method for the synthesis of maleimide derivatives was reported.Fifteen maleimide derivatives were synthesized by a two-step reaction of ring opening amidation and dehydration cyclization.The structures were confirmed by 1H NMR.

关 键 词：顺丁烯二酸酐 马来酰亚胺衍生物 合成 开环 酰胺化 

分 类 号：O624.6[理学—有机化学] O626[理学—化学]