高血压血液微循环功能障碍及其机制研究进展  

Advances in Hypertensive Blood Microcirculation Dysfunction and Its Mechanism

作　　者：李璐含 仉红刚[1] LI Lu-han;ZHANG Hong-gang(Institute of Microcirculation,Chinese Academy of Medical Sciences&Peking Union Medical College,Key Laboratory of microcirculation,Ministry of Health,Beijing 100005,China)

机构地区：[1]北京协和医学院中国医学科学院微循环研究所卫生部微循环重点实验室

出　　处：《微循环学杂志》2019年第3期64-68,74,共6页Chinese Journal of Microcirculation

基　　金：中国医学科学院医学与健康科技创新工程(2016-I2M-3-006)

摘　　要：外周循环阻力增加是原发性高血压发生发展的重要环节,血液微循环中的小动脉侧是阻力血管的主要组成部分,血液微循环功能障碍与高血压密切相关。在高血压中,血液微循环功能的变化主要与微血管数量和微血管结构有关。内皮细胞凋亡,或继发于血管内皮一氧化氮(NO)释放不足导致的血管生成不足,可能造成微血管稀疏,微血管稀疏既作为高血压早期的危险因素出现,也随着高血压进程而加重;血压增加引起小动脉血管壁与官腔比(h/R)增加,可能会放大高血压刺激因素的效果,形成恶性循环,并影响大动脉的结构改变。The increase of peripheral microvascular resistance is an important link in the occurrence and development of hypertension,and the arteriolar side of microcirculation is the main component of vascular resistance.Blood Microcirculation dysfunction is closely related to hypertension.In hypertension,the changes of microcirculation function mainly lie in the changes of number of microvascular and structure of microvascular.Deficiency angiogenesis caused by endothelial cell apoptosis or subsequent insufficient NO release from vascular endothelium may lead to microvascular rarefaction,microvascular rarefaction is not only a risk factor for early hypertension,but also aggravated with hypertension.The increase in h/R ratio of arterioles caused by increased blood pressure may magnify the effect of hypertensive stimuli,form a vicious cycle,and affect the structural changes of arterioles.

关 键 词：高血压 血液微循环 微血管稀疏 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病] R331.35[医药卫生—内科学]