N^6-甲基腺嘌呤RNA修饰研究进展  

Research Progress of N^6-methyladenosine RNA Modification

作　　者：刘畅 陈洪艳 张琦 张心扬[1,2,3] 李辉 程博涵 LIU Chang;CHEN Hongyan;ZHANG Qi;ZHANG Xinyang;LI Hui;CHENG Bohan(Key Laboratory of Chicken Genetics and Breeding,Ministry of Agriculture and Rural Affairs,Harbin,Heilongjiang 150030;Key Laboratory of Animal Genetics,Breeding and Reproduction,Education Department of Heilongjiang Province,Harbin,Heilongjiang 150030;College of Animal Science and Technology,Northeast Agricultural University,Harbin,Heilongjiang 150030)

机构地区：[1]农业农村部鸡遗传育种重点实验室,黑龙江哈尔滨150030 [2]黑龙江省普通高等学校动物遗传育种与繁殖重点实验室,黑龙江哈尔滨150030 [3]东北农业大学动物科学技术学院,黑龙江哈尔滨150030

出　　处：《中国家禽》2019年第14期50-54,共5页China Poultry

基　　金：国家高技术研究发展计划(863计划)项目(2013AA102501);现代农业产业技术体系建设专项资金(CARS-41);黑龙江省高校青年创新人才培养资金项目(UNPYSCT-2018145)

摘　　要：N^6-甲基腺嘌呤(N^6-methyladenosine,m6A)作为一种重要的表观遗传修饰方式,在干细胞命运决定、精子形成、肌肉发育、脂肪沉积及人类肿瘤发生中发挥重要作用。m^6A修饰最重要的作用是调控基因表达,它是细胞中基因表达调控的表观遗传学机制之一。文章综述了m^6A调控基因表达的分子机制及m^6A介导的生物学功能的研究进展,探讨了m^6A RNA甲基化的研究趋势和未来发展方向。N^6-methyladenosine(m^6 A) RNA modification is an important epigenetic modifcation and plays crucial roles in stem cell fate determination, spermatogenesis, muscle development, fat deposition and human tumorigenesis. The key role of m^6A methylation is the regulation of gene expression, and m^6A methylation is one of several epigenetic mechanisms that cells use to regulate gene expression. This review focuses on recent advances of the mechanisms of m^6A regulating gene expression and biological function mediated by m^6A, and discusses the ongoing trends and future research directions of m^6A RNA methylation.

关 键 词：N6-甲基腺嘌呤(m^6A) RNA化学修饰 基因表达调控 生物学功能 

分 类 号：S813.1[农业科学—畜牧学] S813.2[农业科学—畜牧兽医]