人巨细胞病毒感染和细胞自噬  

Human cytomegalovirus and autophagy:recent research progress

作　　者：钱春艳[1,2,3] 龚芳 QIAN Chun-yan;GONG Fang(Yuhang District First Peopled Hospitals Hangzhou,Zhejiang 311100,China;The Second Affiliated Hospital of School of Medicine of Zhejiang University,Hangzhou,Zhejiang 311100,China;School of Life Sciences,Fudan University,Shanghai,200433,China)

机构地区：[1]杭州市余杭区第一人民医院,浙江杭州311100 [2]浙江大学医学院附属第二医院余杭分院,浙江杭州311100 [3]复旦大学生命科学学院,上海200433 [4]江南大学附属医院,江苏无锡214041

出　　处：《中国病毒病杂志》2019年第4期311-314,共4页Chinese Journal of Viral Diseases

基　　金：国家自然科学基金(81601831);江苏省第十四批“六大人才高峰”资助项目(2017-WSN-186);江苏省“科教强卫”青年医学人才项目(QNRC2016203);杭州市科技发展计划项目(20150633B66);杭州市余杭区医疗卫生科研重点学科建设项目(2015008)

摘　　要：人巨细胞病毒(human cytomegalovirus,HCMV)为疱疹病毒β亚科双链线性DNA病毒,具有“潜伏-再激活”感染的生物学特性。我国成人普遍感染。HCMV初次感染健康个体后无临床症状或者临床症状不明显,随后转为潜伏感染状态。由于疾病或其他原因导致机体免疫功能低下时,潜伏的HCMV活化可造成严重后果。HCMV感染的发病机制尚不十分清楚,可能与病毒毒力、组织嗜性以及宿主免疫功能状态等众多因素相关。本文从HCMV感染(包括激活感染和潜伏感染)的临床表现、感染的细胞及器官、与细胞自噬等多个方面,分别进行介绍。Human cytomegalovirus(HCMV),a member of the Betaherpesvirinae subfamily,is a doublestranded linear DNA virus,which characteristically establishes a latent infection that may be reactivated later.HCMV infection in adults is common in China.For the primary infection,HCMV causes no clinical symptoms or no obvious clinical symptoms in healthy individuals,and then a latent infection occurs.The latent HCMV can be reactivated in immunocompromised hosts due to diseases or other reasons,resulting in serious consequences.The pathogenesis of HCMV infection remains unclear.It is proposed that it may be related to virulence,tissue tropism and host immune competence.In this review,we summarize several aspects of HCMV infection including activated and latent infections,clinical manifestations,infected cells and organs?and its interactions with cell autophagy.

关 键 词：人巨细胞病毒 激活感染 潜伏感染 细胞自噬 机制 

分 类 号：R373.9[医药卫生—病原生物学]