18F标记芳环类PET显像剂方法的研究进展  

Methodological progress of 18F-labeled aromatic PET radiotracers

作　　者：古望军 朱明乔[1] 李征 任荣[1] 和庆钢[1] 张宏[3] Gu Wangjun;Zhu Mingqiao;Li Zheng;Ren Rong;He Qinggang;Zhang Hong(College of Chemical and Biochemical Engineering,Zhejiang University,Hangzhou 310027,China;State Key Laboratory of Bioorganic&Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;Department of Nuclear Medicine,Second Affiliated Hospital of Zhejiang University School of Medicine,Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University,Key Laboratory of Medical Molecular Imaging of Zhejiang Province,Hangzhou 310009,China)

机构地区：[1]浙江大学化学工程与生物工程学院,杭州310027 [2]中国科学院上海有机化学研究所生命有机化学国家重点实验室,200032 [3]浙江大学医学院附属第二医院核医学科、浙江大学核医学与分子影像研究所、浙江省医学分子影像重点实验室,杭州310009

出　　处：《中华核医学与分子影像杂志》2019年第8期499-503,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家杰出青年科学基金(81425015);国家自然科学基金(81327004);国家科技支撑计划(2012BAI13B06)

摘　　要：PET显像技术是先进的显像技术之一,其发展与正电子核素标记的PET显像剂密切相关。在众多正电子核素中,18F具有理想的物理性质,成为PET显像剂中最常用的核素。18F标记芳环类PET显像剂因其特殊的代谢稳定性而受到重视。然而,由于缺乏高选择性、高放射性产率和高纯度产物的18F标记方法,18F标记芳环类显像剂的发展和应用受到一定限制。该文从芳环的亲电以及亲核取代反应等方面,对18F标记芳环类显像剂新的标记方法进行综述。PET serves as one of the most advanced imaging modalities,and its development depends on the improvement of radiotracers.Among numerous positron isotopes,18F appears to be the best radionuclide candidate for PET radiotracers by virtue of its favorable physical characteristics.18F-labeled aromatic radiotracers have been widely investigated by researchers due to its special metabolic stability.However,the development and application of 18F-labeled aromatic radiotracers have been limited due to lacking of radiochemical methods to obtain products with high selectivity,high radioactivity and high purity.This review focuses on the new labeling methods of 18F-labeled aromatic radiotracers from the aspects of electrophilic and nucleophilic substitution reactions.

关 键 词：烃类 芳香 同位素标记 氟放射性同位素 正电子发射断层显像术 发展趋势 

分 类 号：R81[医药卫生—放射医学]