参元益气活血胶囊对不稳定型心绞痛患者代谢组学的影响  

Effects of Shenyuan Yiqi Huoxue Capsule On Metabolomics of Patients with Unstable Angina

作　　者：仇盛蕾[1] 孙博[2] 颜贤忠[2] 韩垚[1] 尚菊菊[1] 刘红旭[1] QIU Sheng-lei;SUN Bo;YAN Xian-zhong;HAN Yao;SHANG Ju-ju;LIU Hong-xu(Department of Cardiology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing,100010;Biomedical Analysis Center,Chinese People's Liberation Army Academy of Military Medical Sciences,Beijing,100850)

机构地区：[1]首都医科大学附属北京中医医院心血管科,北京100010 [2]中国人民解放军军事医学科学院生物医学分析中心,北京100850

出　　处：《中国中西医结合杂志》2019年第8期921-926,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市自然科学基金青年基金项目(No.7154207)

摘　　要：目的观察参元益气活血胶囊对不稳定型心绞痛患者代谢组学的影响。方法采用随机对照的研究方法,将100例不稳定型心绞痛患者随机分为对照组和治疗组,每组50例。对照组采用西医常规治疗,治疗组在西医常规治疗基础上联合参元益气活血胶囊,疗程均为4周。观察两组中医症状量化积分、心绞痛发作次数和持续时间,评价临床疗效。对各组患者血清进行弛豫编辑实验和扩散编辑实验,分析各组代谢组学特点。结果与本组治疗前比较,治疗后两组患者中医症状积分降低,心绞痛发作次数和持续时间降低(P<0.05);与对照组比较,治疗组中医症状积分、心绞痛发作次数和持续时间降低更明显(P<0.05)。代谢组学研究显示:治疗后治疗组患者代谢产物更接近健康人群。其中驰豫编辑实验筛选出标志性的代谢产物有:不同化学位移的脂蛋白、乳酸、丙氨酸和糖类;扩散编辑实验筛选出标志性的代谢产物有:不同化学位移的极低密度脂蛋白、低密度脂蛋白、多不饱和脂肪酸、不饱和脂肪酸及脂质。结论西医治疗基础上联合参元益气活血胶囊治疗不稳定型心绞痛,其代谢产物更接近健康人群。Objective To observe the effects of Shenyuan Yiqi Huoxue Capsule(SYHC)on metabolomics of patients with unstable angina.Methods Totally 100 patients with unstable angina were randomly assigned to treatment group and control group,50 in each group.Patients in the control group received routine therapy of Western medicine,patients in the treatment group received SYHC combined with the routine therapy of Western medicine.After 4 weeks treatment,the quantified scores of traditional Chinese medicine(TCM)symptoms,the frequency and duration of angina attacks were observed.Carr-purcell-meiboom-gill(CPMG)test and longitudininal eddy-delay(LED)test were carried out to analyze the metabolomic characteristics of each group.Results Compared with before treatment,the scores of TCM symptoms,the frequency and duration of angina attacks in the two groups were significantly reduced after treatment(P<0.05).Compared with the control group,the scores of TCM symptoms,the frequency and duration of angina attacks were decreased more significantly(P<0.05).Metabolomics studies showed that metabolites of patients in the treatment group were closer to the healthy people after treatment.The metabolomic markers identified by CPMG test are some lipoprotein,lactate,alanine and sugars.Some very low-density lipoprotein(VLDL),low-density lipoprotein(LDL),polyunsaturated fatty acids(PUFA),unsaturated fatty acids(UFA)and lipid are the metabolomic markers identified by LED test.Conclusion SYHC combined with Western medicine in the treatment of unstable angina has a better effect,and the metabolites are closer to healthy people.

关 键 词：代谢组学 参元益气活血胶囊 不稳定型心绞痛 

分 类 号：R54[医药卫生—心血管疾病]