妇科癌症患者癌症相关性认知功能损害的神经心理学研究  

Neuropsychological Study of Cancer-related Cognitive Impairment in Women with Gynecological Cancer

作　　者：张扬[1] 罗太珍[2] 林燕珊[1] 安春燕[1] 曾细根[1] ZHANG Yang;LUO Tai-zhen;LIN Yan-shan;AN Chun-yan;ZENG Xi-gen(Reproductive Medicine Center,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;Gynecology and Obstetrics Research Center,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China)

机构地区：[1]广州医科大学附属第三医院生殖医学中心,广东广州510150 [2]广州医科大学附属第三医院妇产科研究所,广东广州510150

出　　处：《护理学报》2019年第15期70-75,共6页Journal of Nursing（China）

基　　金：广东省医学科研基金项目(A2015141)

摘　　要：目的了解妇科癌症患者癌症相关性认知功能损害的神经心理学特点。方法采用逻辑记忆测试、词语流畅性测试、Stroop色词干扰测试、连线测试A、医院焦虑抑郁量表、中文版简明疲劳量表,对研究组146例妇科癌症患者、健康对照组112例健康成年女性进行调查,比较2组得分差异性和指标间的相关性。结果(1)神经心理学测试结果显示,研究组在Stroop色词测试文字阅读、颜色阅读中耗时、连线测试A中耗时大于健康对照组人群(P<0.05);研究组在词语流畅性测试、逻辑记忆测试中得分均低于健康对照组人群(P<0.05);(2)相关性分析结果显示,即时记忆得分、词语流畅性测试总分与抑郁得分呈一定负相关(r=-0.164,-0.214,P<0.05);Stroop色词干扰测试总耗时、连线测试A耗时与抑郁得分呈一定正相关(r=0.183,0.275,P<0.05);词语流畅性测试总分与焦虑得分呈一定负相关(r=-0.267,P<0.05);连线测试A耗时与焦虑得分呈一定正相关(r=0.196,P<0.05);Stroop色词干扰测试总耗时、连线测试A与疲劳得分呈一定正相关(r=0.258,0.196,P<0.05)。结论妇科癌症患者存在不同程度的癌症相关性认知功能损害,主要表现为注意力、记忆力、语言功能和执行功能的改变,且与焦虑、抑郁和疲劳存在一定的相关性。Objective To investigate the neuropsychological characteristics of cancer-related cognitive impairment(CRCI)in women with gynecological cancer.Methods Verbal fluency test(VFT),stroop color words test(SCWT),trail making test A(TMTA),logical memory test(LM),Hospital Anxiety and Depression Scale(HADS),Chinese Version of the Brief Fatigue Inventory(BFI-C)were conducted to investigate 146 patients with gynecologic cancer(study group)and 112 healthy controls(control group).Results(1)Neuropsychological test showed that time-consuming of stroop test A,stroop test B and TMT-A test in study group were longer(P<0.05)but the scores of VFT and logical memory test were lower in study group than those in the control group(P<0.05);(2)Correlation analysis showed that immediate memory and VFT were negatively correlated with depression(r=-0.164,-0.214,P<0.05)but stroop and TMT-A positively with it(r=0.183,0.275,P<0.05).VFT was negatively correlated with(r=-0.267,P<0.05)but TMT-A positively with anxiety(r=0.196,P<0.05).Stroop and TMT-A were positively correlated with fatigue(r=0.258,0.196,P<0.05).Conclusion CRCI exists in gynecological cancer survivors in varying degrees,demonstrated by the change of attention,memory,language and executive function,and there is correlation between CRCI and anxiety,depression and fatigue.

关 键 词：妇科癌症 患者 认知功能损害 癌症相关性 神经心理学 

分 类 号：R47[医药卫生—护理学]