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作 者:夏延哲[1] 陈斯乐[2] 伍晶晶 陈孝[1] 张信华[2] XIA Yan-zhe;CHEN Si-le;WU Jing-jing;CHEN Xiao;ZHANG Xin-hua(Department of Pharmacy,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Gastrointestinal Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou510080,China)
机构地区:[1]中山大学附属第一医院药学部,广东广州510080 [2]中山大学附属第一医院胃肠外科,广东广州510080
出 处:《消化肿瘤杂志(电子版)》2019年第3期245-248,共4页Journal of Digestive Oncology(Electronic Version)
摘 要:目的考察服用伊马替尼胃肠间质瘤患者的全血样本在室温下血浆药物浓度的稳定性。方法采用LC/MS/MS方法,2 mmol·L^-1甲酸铵溶液-乙腈(3:7)为流动相,以d8-伊马替尼为内标。取10名规律服用伊马替尼至少1月患者的无菌全血样本,室温分别放置0、6、12、24、48、72 h后提取血浆,进行检测。结果10名患者均为胃肠间质瘤患者,男性7名,中位年龄52(35-62)岁,伊马替尼服药剂量300-400 mg/d,10例患者无菌全血样本室温放置0、6、12、24、48、72 h后测得结果的RSD均小于15%。结论室温下伊马替尼的无菌全血样本放置72 h内血浆药物浓度稳定,全血样本室温放置3 d内检测结果可信。Objective To investigate the stability of imatinib in whole blood of gastrointestinal stromal tumor patients at room temperature.MethodsLC/MS/MS was performed,2 mmol·L^-1 ammonium formate solution and acetonitrile(3:7)as the mobile phase,d8-imatinib as the internal standard.The whole blood samples from 10 patients who were administrated imatinib at least one month,were maintained at room temperature in 0,6,12,24,48,72 h respectively.Then the plasma contained imatinib from all the samples was extracted and detected.Results10 patients were all diagnosed as gastrointestinal stromal tumors and administrated 300-400 mg imatinib per day,seven of them were male,the median age was 52(35-62),intra-batch and inter-batch of different time RSDs were all<15%.Conclusionthe plasma concentrations of imatinib were stable which were extracted from whole blood at room temperature in 72 h,suggesting the concentration of imatinib results were acceptable when whole blood samples were placed within 3 days at room temperature.
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