恶性肿瘤生物样本信息数据库的构建及应用  

Construction and application of biobank information database for malignant tumors

作　　者：蒋雪莉 李慧[2] 柳菁菁[3] 张琳娜[1] 李文秀 姚洁 程颖[1,2,3] Jiang Xueli;Li Hui;Liu Jingjing;Zhang Linna;Li Wenxiu;Yao Jie;Cheng Ying(Biobank,Jilin Cancer Hospital,Changchun 130012,China;Translational Cancer Research,Jilin Cancer Hospital,Changchun 130012,China;Department of Medical Thoracic Oncology,Jilin Cancer Hospital,Changchun 130012,China)

机构地区：[1]吉林省肿瘤医院生物样本库,长春130012 [2]吉林省肿瘤医院肿瘤转化医学实验室,长春130012 [3]吉林省肿瘤医院胸部肿瘤内科,长春130012

出　　处：《中华临床实验室管理电子杂志》2019年第3期184-189,共6页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

基　　金：吉林省科技厅资助项目(20170622005JC);吉林省科技厅资助项目(20180101008JC);吉林省卫生厅资助项目(2017J023)

摘　　要：目的生物样本库对临床转化性研究具有重要的推动作用,随着生物样品数量的日益增加和研究需求的多样性,传统的电子表格管理模式已不能满足庞大样品量及其临床信息高效、集中管理的需求。因此迫切需要对生物样本实行信息化管理,构建恶性肿瘤生物样本及临床信息的信息化管理体系,以实现生物样本信息的系统化、规范化、高效化管理。方法以恶性肿瘤生物样本信息数据库为依托,对恶性肿瘤样品源及样品信息进行结构化设计,通过恶性肿瘤样品组、样品源组、虚拟医用冰箱的构建,整合恶性肿瘤患者基本信息、临床信息等相关信息,并实现查询统计功能。结果成功构建了恶性肿瘤生物样本数据库,包含样品组、样品源组、虚拟医用冰箱组,实现了生物样本的查询统计应用,包括各癌种的样品量统计、各科室血液样品和组织样品的采集量统计,以及对样品管出库管理的应用。结论构建的恶性肿瘤生物样本信息数据库,数据信息完整、结构设计合理,样品组信息具有可扩展性。该数据库满足了我院当前生物样本数据信息化管理的需求,实现了多项查询统计应用和出库应用,为相关恶性肿瘤疾病的研究提供了可靠保障。Objective Biobank plays an important role in translational cancer research.With the rapid increasing number of biosamples and the diversity of research needs,the traditional spreadsheet management model can not satisfy the needs of large sample number and efficient and centralized management of clinical information.Therefore,it is an urgent need to carry out information management of biobank and to build an information management system for biosamples and clinical information of malignant tumors in order to achieve systematic,standardized and efficient management of biosample information.Methods Based on malignant tumor biobank information database,the source and sample information are structurally designed.Through the construction of sample group,sample source group and virtual medical refrigerator,the basic and clinical information of patients with malignant tumors is integrated,and the query and statistics function is realized.Results The database of malignant tumor biobank has been successfully constructed,including sample group,sample source group and virtual medical refrigerator group.The application of query and statistics of biosamples has been realized,including the statistics of samples of various cancers,blood samples and tissue samples collected from various departments,and the application of sample tube discharge management.Conclusions The database of malignant tumor biobank information is constructed,which has completed data information,reasonable structure design and expansibility of sample group information.The database satisfies the current needs of the information management of biosample data in our hospital,realizes a number of query.statistics application and outbound applications,and provides a reliable guarantee for the research of related malignant tumors.

关 键 词：恶性肿瘤 生物样本库 信息化管理 数据库 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]