2种中草药组方减肥功能的动物试验研究  

Animal Experimental Study on the Weight Loss Function of Two Kinds of Chinese Herbal Medicine on the Obese Rats

作　　者：陶倩 金鑫 刘硕 马思遥 吴松青 吴赟 TAO Qian;JIN Xin;LIU Shuo(Infinitus(China)Co.,Ltd.,Guangzhou,Guangdong 510623)

机构地区：[1]无限极(中国)有限公司,广东广州510623 [2]广东中大南海海洋生物技术工程中心有限公司,广东广州510275

出　　处：《安徽农业科学》2019年第17期169-173,共5页Journal of Anhui Agricultural Sciences

摘　　要：[目的]为探讨2种中草药组方的潜在减肥效果,成功构建肥胖大鼠试验模型。[方法]在连续饲养8周后,取肥胖大鼠的肝脏和脂肪组织称重,检测3项血清生化指标和大鼠体内14项肥胖相关因子水平,并将相关结果进行统计学分析。[结果]2种受试样品都能够降低肥胖大鼠的体重和脂肪重量,改善血清中血糖、甘油三酯和胆固醇的水平;降低下丘脑中神经肽Y的水平、肝脏中脂肪酸合成酶的活性、血清中生长激素释放肽、生长激素和胰岛素的浓度;升高下丘脑中瘦素和血清中胰高血糖素样肽-1的浓度。[结论]2种受试样品对肥胖模型大鼠都有一定的减肥作用,有进一步开发成减肥类产品的潜力。[Objective]The research aimed to investigate the potential effects of two formulas of Chinese herbal medicine that offer weight loss,the rat model of obesity induced by high-fat diet was established.[Method]After 8 weeks of continuous feeding,the weight of liver and adipose tissues of the obese rats were measured;three serum biochemical indicators and 12 obesity-related factors in vivo were detected;and the results were analyzed statistically.[Result]Both of the two samples could reduce the body weight and fat weight of obese model rats,and improve the levels of glucose,triglyceride and cholesterol in serum,and decrease the contents of NPY in hypothalamus,FAS in liver,ghrelin,GH,INS in serum,and increase the contents of leptin in hypothalamus and GLP-1 in serum.[Conclusion]The two samples have a certain effects of weight loss on the obese model rats,and have the potential to develop weight loss products furtherly.

关 键 词：中草药组方 肥胖模型大鼠 肥胖相关因子 减肥 功能 

分 类 号：R285.5[医药卫生—中药学]