68Ga标记药物研究进展  

The Research Progress of 68Ga Generator and 68Ga Radiopharmaceuticals

作　　者：郭志德 张现忠[2] 杜进[1,3] GUO Zhide;ZHANG Xianzhong;DU Jin(Department of Isotope,China Institute of Atomic Energy,Beijing 102413,China;Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China;China Isotope&Radiation Corporation,Beijing 100045,China)

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413 [2]厦门大学分子影像暨转化医学研究中心,福建厦门361102 [3]中国同辐股份有限公司,北京100045

出　　处：《同位素》2019年第5期360-374,I0004,共16页Journal of Isotopes

基　　金：博士后创新人才支持计划(BX201700142);中国博士后科学基金面上项目(2018M630732);国家自然科学基金(81471707)

摘　　要：正电子发射型计算机断层显像(positron emission tomography,PET)是核医学领域重要的诊断及显像工具,在基础医学诊断、新药研发和疗效评价等各方面发挥越来越重要作用。18 F是PET显像最常用的核素,但18 F需要加速器生产。68 Ga为PET显像核素,可以从长寿命的68 Ge/68 Ga发生器装置获得,不必依赖加速器。随着配位化学的发展,各种双功能螯合剂用于68 Ga的标记,可将68 Ga与多种化学结构及生物分子连接并且可以药盒化68 Ga标记药物。本文主要介绍近期68 Ga标记放射性药物的研究进展。Positron emission tomography(PET)is an important diagnosis and imaging tool for nuclear medicine,and playing an increasing part in fundamental medicine,new drug research and clinical effect assessment,etc.18 F is the most common radionuclide for PET imaging,which is produced in a cyclotron.68 Ga is a PET imaging radionuclide of increasing concern,and is gained from long-lived 68 Ge/68 Ga generator systems.The use of 68 Ga does not demandan on-site cyclotron,which provide a convenient method for researchers.With the development of coordination chemistry,a variety of bifunctional chelators have been developed for 68 Ga labeling,which allow the convenient coupling tomany chemical structures and biomolecules.Kit-formulated preparation is another advantage for 68 Ga radiopharmaceuticals.This review presents the developments of the 68 Ga-based radiopharmaceuticals.

关 键 词：PET显像 68 Ga发生器 68 Ga标记药物 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.4[医药卫生—影像医学与核医学]