阿法骨化醇与吡格列酮治疗多囊卵巢综合征疗效及对胰岛素抵抗影响  

Effect of alfacalcitol combined with pioglitazone for treating women with polycystic ovary syndrome, and its influence on insulin resistance

作　　者：汪学敏 黄育红[1] WANG Xuemin;HUANG Yuhong(The Second People's Hospital of Wuhu City,Anhui Province,241000)

机构地区：[1]安徽省芜湖市第二人民医院

出　　处：《中国计划生育学杂志》2019年第8期1003-1006,共4页Chinese Journal of Family Planning

摘　　要：目的:观察阿法骨化醇与吡格列酮治疗多囊卵巢综合征(PCOS)临床疗效及对胰岛素抵抗影响。方法:纳入2015年7月-2016年7月本院收治的PCOS患者86例,根据随机数字表法均分两组,对照组给予吡格列酮联合促排卵方案治疗,观察组在对照组治疗基础上加以阿法骨化醇治疗,对比两组治疗前后胰岛素抵抗水平、性激素和排卵情况,随访1年自然受孕情况。结果:较治疗前比较,治疗后两组胰岛素抵抗指标(FINS、FPG、2hPG、HOMA-IR)均降低,HOMA-β水平上升(P<0.05);性激素(E2、T、LH、FAI、FSH、LH/FSH)水平均下降(P<0.05),且促黄体生成素(LH)水平观察组低于对照组(P<0.05),其他性激素水平两组比较无差异(P>0.05);观察组排卵率、促排卵天数和成熟卵泡数与对照组比较无差异(P>0.05),妊娠率(55.8%)与对照组(44.2%)比较无差异(P>0.05)。结论:阿法骨化醇联合吡格列酮治疗PCOS可显著改善患者的胰岛素抵抗,调节糖代谢紊乱,对性激素水平和排卵状况未见明显影响。Objective:To investigate the effect of alfacalcidol combined with pioglitazone for treating women with polycystic ovary syndrome(PCOS),and to explore its influence on the insulin resistance of women.Methods:86 women with PCOS patients were divided into two groups according to the random number table group.The women in the observation group were treated by alfacalciferol combined with pioglitazone,the women in the control group were treated by pioglitazone only.The situations of insulin resistance and ovulation,and sex hormones levels of women were compared between the two groups before and after treatment.The natural fertility rate of women in both groups was followed up.Results:The levels of FINS,FPG,2hPG,and HOMA IR,and the levels of E 2,LH/FSH,T,LH,FAI,and FSH of women in both groups had decreased significantly after treatment(P<0.05),but HOMAβlevels of all women was significantly increased(P<0.05).The LH level of women in the observation group was significant lower than that of women in the control group(P<0.05),but there were no significant different in the levels of LH/FSH,T,LH,AI,and FSH of women between the two groups(P>0.05).The ovulation rate,the days ovulation promoted,and number of mature follicles after treatment of women in the observation group had no significant different from those of women in the control group(P>0.05).The pregnancy rate of women in the observation group was 55.8%,which had no significant different from that(44.2%)of women in the control group(P>0.05).Conclusion:Alfacalcidol combined with pioglitazone for treating women with PCOS can significantly alleviate the insulin resistance of women,and can regulate glucose metabolism disorders without influencing on sex hormone levels and ovulation status of women.

关 键 词：多囊卵巢综合征 阿法骨化醇 吡格列酮 性激素 胰岛素抵抗 

分 类 号：R71[医药卫生—妇产科学]