早发型重度子痫前期母血中Ghrelin和SP1表达与胎儿生长受限关系  

The relationships between the expressions of serum Ghrelin、SP1 and their fetal growth restriction in pregnant women with early onset severe preeclampsia

作　　者：冯海英 FENG Haiying(Linqing People's Hospital,Shandong Province,252600)

机构地区：[1]山东省临清市人民医院

出　　处：《中国计划生育学杂志》2019年第8期1022-1026,共5页Chinese Journal of Family Planning

摘　　要：目的:探究早发型重度子痫前期母体血清中生长激素释放肽(Ghrelin)和妊娠特异性β1糖蛋白(SP1)水平的表达,以及与胎儿生长受限(FGR)的相关性。方法:选取124例早发型重度子痫前期者为观察组,另选取正常妊娠80例作为对照组,收集血清,采用酶联免疫法检测Ghrelin、SP1水平,Pearson相关性分析其与胎儿体重的相关性,统计新生儿胎儿生长受限发生率。将观察组产妇分为FGR组、非FGR组,多因素logistic回归分析可能影响因素。受试者工作特征曲线(ROC)评估Ghrelin和SP1对早发型重度子痫前期产妇FGR的诊断价值。结果:观察组124例产妇新生儿为FGR23例(18.5%)。与非FGR组、正常组相比,FGR组产妇血清Ghrelin升高、SP1降低(P<0.05)。Ghrelin、SP1水平分别与新生儿体重成负相关(r=-0.537)和正相关(r=0.452(均P<0.05)。多因素分析显示,孕期体重、尿蛋白、羊水过少、妊娠期高血压疾病、Ghrelin、SP1水平是影响FGR发生的危险因素。Ghrelin诊断FGR的AUC为0.725,截断值为12.1,灵敏度为73.9%,特异度为78.2%;SP1诊断FGR的AUC为0.706,截断值为86.5,敏感性为78.3%,特异性为81.2%。结论:早发型重度子痫前期FGR母体血清中Ghrelin水平升高、SP1水平降低,两者为影响早发型重度子痫前期FGR的独立危险因素,对FGR可能有一定预测价值。Objective:To explore the expressions of the serum growth hormone releasing peptide(Ghrelin)and pregnancy specific β1 glycoprotein(SP1)of pregnant women with early onset severe preeclampsia,and to study their correlations to the fetal growth restriction(FGR).Methods:124 pregnant women with early onset severe preeclampsia were selected into the study group,and other 80 normal pregnant women were selected into the control group.The levels of serum Ghrelin and SP1 of all include women were detected by ELISA.The Pearson correlation analysis was used for studying the relationships between maternal serum Ghrelin and SP1 levels and fetal weight.The women in the study group were divided into FGR group and non FGR group,and the multivariate logistic regression analysis was used to explore the influencing factors.The receiver operating characteristic curve(ROC)was used to evaluate the diagnostic values of Ghrelin and SP1 for FGR of women with early onset severe preeclampsia.Results:23(18.5%)newborns were FGR.Compared to that of women in non FGR group and the control group,the level of serum Ghrelin of women in FGR group had increased significantly and the level of FGR had decreased significantly(P<0.05).The level of serum Ghrelin was significantly negative correlated to the neonatal weight(r=0.537,P<0.05),and the level of SP1 was positive correlated to the neonatal weight(r=0.452,P<0.05).Logistic multifactor analysis showed that pregnancy weight,urine protein,oligohydramnios,hypertensive disorder complicating pregnancy,and the levels of Ghrelin and SP1 were the risk factors of the occurrence of FGR.ROC curve analysis showed that the AUC of Ghrelin level for diagnosing FGR was 0.725 and the cut off value was 12.1,which sensitivity and specificity were 73.9%and 78.2%.The AUC value of SP1 level for diagnosing FGR was 0.706 and the cut off value was 86.5,which sensitivity and specificity were 78.3%and 81.2%.Conclusion:The serum Ghrelin level of the pregnant women with early onset severe preeclampsia and FGR has increased and S

关 键 词：早发型重度子痫前期 胎儿生长受限 生长激素释放肽 妊娠特异性Β1糖蛋白 影响因素 

分 类 号：R71[医药卫生—妇产科学]