滋肾育胎丸联合地屈孕酮治疗黄体功能不全所致复发性流产  

Clinical efficacy of Zishenyutai pills combined with dydrogesterone for treating women with recurrent spontaneous abortion caused by luteal insufficiency

作　　者：张燕萍[1] ZHANG Yanping(The Second People's Hospital of Luqiao District of Taizhou,Zhejiang Province,318058)

机构地区：[1]浙江省台州市路桥区第二人民医院

出　　处：《中国计划生育学杂志》2019年第8期1027-1030,共4页Chinese Journal of Family Planning

摘　　要：目的:观察滋肾育胎丸联合地屈孕酮治疗黄体功能不全复发性流产的临床疗效。方法:2016年8月—2017年8月本院治疗的150例黄体功能不全所致复发性流产患者,随机数字表方式分为两组各75例。对照组予以地屈孕酮片口服治疗,观察组在对照组治疗基础上增加滋肾育胎丸内服,记录两组治疗期间药物不良反应情况,治疗前和妊娠8周血清孕酮(P)、绒毛膜促性腺激素(HCG)、炎症因子(TNF-α、IL-2、IL-6和IL-10)水平变化,评价总疗效,统计保胎成功率和再次流产发生率。结果:两组血清P和HCG水平治疗后均升高,且观察组高于对照组(P<0.05);治疗至妊娠8周,两组血清TNF-α和IL-2水平较治疗前升高,IL-6和IL-10水平较治疗前降低,且观察组TNF-α和IL-2水平高于对照组,而IL-6和IL-10水平低于对照组(P<0.05);观察组治疗有效率(90.7%)、保胎成功率(85.3%)均高于对照组(69.3%、62.7%)(P<0.05);治疗期间观察组药物不良反应发生率(6.7%)与对照组(4.0%)无差异(P>0.05)。结论:较地屈孕酮单纯治疗,联合滋肾育胎丸可显著升高患者血清P和HCG水平,调节炎症相关因子水平,提高总体疗效,缓解相关临床症状,降低再次流产发生率,且安全性较好。Objective:To observe the clinical efficacy of Zishenyutai pills combined with dydrogesterone for treating women with recurrent spontaneous abortion caused by luteal insufficiency.Methods:150 women with recurrent spontaneous abortion(RSA)caused by luteal insufficiency were included and were randomly divided into the study group and the control group(75 cases in each group)from August 2016 to August 2017.The women in the control group were treated by dydrogesterone orally,and the women in the study group were treated by Zishenyutai pills combined with dydrogesterone.The occurrence of adverse drug reactions of women in the two groups during treatment was recorded,and the changes of serum P,HCG,TNF a,IL 2,IL 6 and IL 10 levels of women were compared between the two groups before pregnancy and during 8 gestational weeks.The overall curative effect of women after treatment was evaluated,and the successful rate of tocolytic therapy and the incidence of spontaneous abortion again of all included women during this pregnancy were counted.Results:After treatment,the levels of serum P and HCG of all women had increased significantly(P<0.05),and the levels of serum P and HCG of women in the study group were significant higher than those of women in the control group(P<0.05).During 8 gestational weeks,the levels of serum TNF a and IL 2 of women in both groups had increased significantly after treatment,but the levels of IL 6 and IL 10 had decreased significantly(P<0.05).After women treated to 8 gestational weeks,the levels of serum TNF a and IL 2 of women in the study group were significant lower than those of women in the control group,while the levels of IL 6 and IL 10 were significant higher(P<0.05).The total effective rate and the successful rate of tocolytic therapy of women in the study group were 90.7%and 85.3%,which were significant higher than those(69.3%and 62.7%)of women in the control group(P<0.05).During the treatment,the incidence of adverse drug reactions of women in the study group was 6.7%,which had no signifi

关 键 词：复发性流产 黄体功能不全 滋肾育胎丸 地屈孕酮 临床效果 

分 类 号：R71[医药卫生—妇产科学]