多囊卵巢综合征患者血清Angptl 2、Angptl 4水平与肥胖和糖脂代谢  

The relationships between serum Angptl 2、Angptl 4 Levels and obesity、abnormal glycolipid metabolism in women with polycystic ovary syndrome

作　　者：应雪娇 余琳 王云 王欣[1] 张晓兰[1] YING Xuejiao;YU Lin;WANG Yun;WANG Xin;ZHANG Xiaolan(Hongqiao Hospital of Tianjin,Tianjin,300131;The Third Hospital Affiliated to Guangzhou Medical University)

机构地区：[1]天津市红桥医院,300131 [2]广州医科大学第三附属医院

出　　处：《中国计划生育学杂志》2019年第8期1069-1072,共4页Chinese Journal of Family Planning

摘　　要：目的:分析多囊卵巢综合征(PCOS)患者血清血管生成素样蛋白2(Angptl 2)、血管生成素样蛋白4(Angptl 4)水平,以及与肥胖和糖脂代谢关系。方法:收集本院2014年3月—2017年2月收治PCOS患者156例,根据体质量指数(BMI)分为PCOS肥胖组(BMI≥25 kg/m^2)和PCOS非肥胖组(BMI<25 kg/m2)。另选同期体检健康妇女60例为对照组。测定3组血清Angptl 2和Angptl 4水平、BMI、糖脂代谢指标,Pearson分析血清Angptl 2和Angptl 4水平与糖脂代谢指标关系。结果:PCOS患者血清Angptl 2水平高于对照组,Angptl 4水平低于对照组,且PCOS肥胖组血清Angptl 2水平高于非肥胖组,Angptl 4水平低于非肥胖组,Angptl 2与Angptl 4呈负相关(均P<0.05)。PCOS患者FINS、HOME-IR、PGB30、INS30、HOMEM30、TG和TG/HDL-C高于对照组,HDL-C低于对照组,PCOS患者血清Angptl 2水平与FINS、HOME-IR、PGB30、INS30、HOME-M30、TG和TG/HDL-C水平正相关,与HDL-C水平负相关,血清Angptl 4水平与FINS、HOME-IR、PGB30、INS30、HOMEM30、TG和TG/HDL-C水平负相关,与HDL-C水平正相关(均P<0.05)。结论:PCOS患者血清Angptl 2水平升高,Angptl 4水平降低,与PCOS患者肥胖和糖脂代谢有关。Objective:To analyze the serum levels of angiopoietin like protein 2(Angptl 2)and angiopoietin like protein 4(Angptl 4)of women with polycystic ovary syndrome(PCOS),and to explore the relationships between the serum Angptl 2 and Angptl 4 Levels and the rate of obesity and abnormal glycolipid metabolism of these women.Methods:156 women with PCOS were divided into obesity group(BMI≥25kg/m^2)and non obesity group(BMI<25kg/m 2)according to BMI index.Another 60 healthy women were selected in the control group.Serum Angptl 2 and Angptl 4 levels,body mass index,glycometabolism indexes and lipid metabolism indexes were detected.Pearson analysis was used to study the relationships between the levels of serum Angptl 2 and Angptl 4 and the values of glycolipid metabolism indexes.Results:The serum Angptl 2 level of women with PCOS was significant higher than that of healthy women,the level of Angptl 4 was significant lower than that of healthy women(P<0.05).The level of serum Angptl 2 of women in PCOS obesity group was significant higher than that of women in non obesity group,but the level of Angptl 4 was significant lower(P<0.05).The level of Angptl 2 was negatively correlated to the level of Angptl 4(P<0.05).The values of FINS,HOME IR,PGB30,INS30,HOME M30,TG and TG/HDL C of women with PCOS were significant higher than those of women in the control group,the HDL-C level was significant lower than that of women in the control group(P<0.05).Serum Angptl 2 level of women with PCOS was positively correlated to their levels of FINS,HOME IR,PGB30,INS30,HOME M30,TG and TG/HDL C(P<0.05),but was negatively correlated to the HDL C level(P<0.05).Serum Angptl 4 levelof women with PCOS were negatively correlated to the levels of FINS,HOME IR,PGB30,INS30,HOME M30,TG and TG/HDL-C,but positively correlated to the HDL-C level(P<0.05).Conclusion:The level of serum Angptl 2 of women with PCOS increases and the level of Angptl 4 decreases significantly,which is associated with obesity and abnormal glycolipid metabolism of women with PCOS.

关 键 词：多囊卵巢综合征 血管生成素样蛋白2 血管生成素样蛋白4 肥胖 糖脂代谢 

分 类 号：R71[医药卫生—妇产科学]