安宫黄体酮联合Gn促排卵与GnRHa长方案促排卵用于冻融囊胚移植中的临床效果  

The clinical effect of medroxyprogesterone acetate or GnRH-a long protocol promoting ovulation for treating women with frozen-thawed blastocysts transfer

作　　者：江成龙[1] 张昌军[1] JIANG Chenglong;ZHANG Changjun(People’s Hospital of Shiyan City,Hubei Province,442000)

机构地区：[1]湖北省十堰市人民医院

出　　处：《中国计划生育学杂志》2019年第8期1112-1115,共4页Chinese Journal of Family Planning

基　　金：湖北医药学院重点学科建设经费项目资助(2017XKJSSJ08)

摘　　要：目的:比较安宫黄体酮(MPA)联合促性腺激素(Gn)促排卵与促性腺激素释放激素激动剂(GnRHa)长方案垂体降调节促排卵在冻融囊胚移植中的临床效果。方法:回顾分析617周期冻融囊胚移植的临床资料,根据促排卵方案分为MPA联合Gn组(MPA组,241例)和GnRHa长方案垂体降调节促组(GnRHa组,376例),比较两组促排卵参数。结果:MPA组与GnRHa组比较,Gn使用天数(8.8±2.1d,10.8±1.6个d)、Gn使用剂量(2038.6±678.5U,2276.4±854.6U)、获卵数(7.1±2.4个,12.1±2.5个)、可用胚胎数(3.9±1.1个,5.4±1.9个),优胚数(3.1±1.2个,4.4±1.9个)和囊胚数(2.9±1.2个、4.1±2.0个)均有差异(P<0.05)。冻融囊胚移植种植率和临床妊娠率,两组比较无差异(P>0.05)。结论:MPA联合Gn促排卵与经典长方案促排卵在冻融囊胚移植中具有相似的种植潜能,但减少了Gn使用剂量,故可降低治疗费用。Objective:To compare the clinical effect of promoting ovulation between medroxyprogesterone acetate(MPA)used and gonadotropine(GnRH a)long protocol used for treating women with frozen thawed blastocysts transfer.Methods:The data of 617 treatment cycles of women with ovarian stimulation protocol were retrospective analyzed.The women were divided into group A(241 women treated by MPA combined with Gn protocol)and group B and(376 women treated by long GnRHa protocol).The parameters of ovulation induction of women were compared between the two groups.Results:The days of Gn used,the dosage of Gn used,the number of retrieved oocytes,the number of available embryos,the number of quality embryos,and the number of blastocysts of women in group A were 8.8±2.1d,2038.6±678.5 U,7.1±2.4 pieces,3.9±1.1 piece,3.1±1.2 piece,3.9±1.1 piece,and 2.9±1.2 piece,respectively,which were significant higher than those(10.8±1.6d,2276.4±854.6U,12.1±2.5 piece,5.4±1.9 piece,4.4±1.9 piece,and 4.1±2.0 piece,respectively)of women in group B(P>0.05).Conclusion:Comparing to that of classical long protocol,MPA combined with Gn protocol has the similar implanting potential for frozen thawed embryo transfer cycle,which can decrease the dosage of Gn significantly,so it can reduce the cost of treatment.

关 键 词：冻融胚胎移植 促排卵 安宫黄体酮 长方案 

分 类 号：R71[医药卫生—妇产科学]