蛋白激酶CK2神经生物学特性及功能研究进展  

Advances in neurobiological characteristics and function of protein kinase CK2

作　　者：陈岳彤 武菲 CHEN Yuetong;WU Fei(Neurobiology Institute,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院神经生物学研究所

出　　处：《济宁医学院学报》2019年第4期279-284,共6页Journal of Jining Medical University

基　　金：山东省自然科学基金(ZR2019PC007);济宁医学院青年教师科研扶持基金(JYFC2018KJ022);济宁医学院大学生创新训练计划项目(cx2018031)

摘　　要：蛋白激酶CK2是一种普遍存在的多效性丝/苏氨酸蛋白激酶,在非神经细胞中发挥重要作用。近年来研究证实CK2在神经系统中也扮演不可或缺的角色:CK2在大脑中大量表达,底物众多,通过磷酸化底物参与多种信号通路;在神经元中,CK2存在于突触和细胞核等多种基质,并证实其参与调制神经元发育与生长、突触形成、突触传递、突触的可塑性、学习与记忆等生理活动;一些神经因子或化合物可通过CK2起着神经营养或保护作用。本文将对CK2的生物学特性及神经生物学功能研究的最新进展作一综述。Protein kinase CK2 is a kind of ubiquitous multipotent serine/threonine protein kinase,which plays an important role in non-nervous cells.Recent studies have confirmed that CK2 also shows indispensable effects in the nervous system:(1)CK2 is abundantly expressed in brain and modulates plentiful substrates via phosphorylation participating in many signaling pathways;(2)CK2 exists in synapses,nuclei and other substrates in neurons,and has been proved to be involved in neuronal physiological activities such as development and growth,synaptogenesis and synaptic transmission,synaptic plasticity,learning and memory;(3)some neurokines or compounds could play neurotrophic or neuroprotective roles through CK2.This review will focus on the latest advances in the biological characteristics and neurobiological functions of CK2.

关 键 词：酪蛋白激酶 CK2 神经元 突触传递 神经保护 

分 类 号：R338.2[医药卫生—人体生理学]