转生长激素基因小鼠、猪、羊的研究进展  

Research Progress of Growth Hormone-Transgenic Mice,Pigs and Sheep

作　　者：王立民[1] 周平[1] 唐红[1] 郭延华[1] 张译元[1] 王新华[1] WANG Li-min;ZHOU Ping;TANG Hong;GUO Yan-hua;ZHANG Yi-yuan;WANG Xin-hua(State Key Laboratory of Sheep Genetic Improvement and Healthy Production,Xinjiang Academy of Agricultural and Reclamation Science,Shihezi 832000,China)

机构地区：[1]新疆农垦科学院省部共建绵羊遗传改良与健康养殖国家重点实验室

出　　处：《内蒙古大学学报（自然科学版）》2019年第5期544-549,共6页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学基金(31660341);兵团博士基金项目(2015AG011);国家转基因重大项目(2016ZX08008001)

摘　　要：自美国科学家Palmiter培育出世界上第一只"超级小鼠"以来,动物育种家们掀起了转基因动物新品种培育的研究热潮.从转基因小鼠到转基因猪和羊,虽然转基因个体的体重都有所增加,但是存在的缺陷也很多,尤其是在生殖方面,使得转基因家畜无法应用到实际当中,更多的是作为疾病模型.本文对转生长激素基因小鼠、猪和羊进行了综述,回顾了超级小鼠、猪和羊研究进展以及存在的问题,并对转基因动物进行了展望.In 1982,American scientist Palmiter introduced the fusion gene of mouse metallothionein gene promoter I(MT-I)and rat growth hormone gene(GH)into mice by microinjection,and produced the world’s first "super mouse",which opened an new era of transgenic animal researches,especially on pigs and sheep.From GH transgenic mice to transgenic pigs and sheep,although the body weight of transgenic individuals increased,there had lots of defects,especially in the reproduction performance,which limited their application.In this paper,we summarized the progress of GH transgenic mice,pigs and sheep related researches,reviewed the existing problems of these transgenic animals,and discussed the future of GH transgenic animal research.

关 键 词：生长激素 转基因小鼠 转基因猪 转基因羊 

分 类 号：Q38[生物学—遗传学]