从美国批准遗传修饰三文鱼上市谈我国遗传修饰动物研发及产业化  

From FDA Labeled GMO Salmon to Talk about the Transgenic Animal R&D and Industrialization in China

作　　者：刘颖[1,2] 周荣 李奎[1] LIU Ying;ZHOU Rong;LI Kui(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;School of Life Science and Technology,Inner Mongolia University of Science&Technology,Baotou 010040,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]内蒙古科技大学生命科学与技术学院,内蒙古包头010040

出　　处：《内蒙古大学学报（自然科学版）》2019年第5期550-556,共7页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家转基因生物新品种培育重大专项(2018ZX0801008B,2016ZX08006-001)

摘　　要：转基因三文鱼是首个被批准上市的转基因动物食品,从而让转基因动物从科学研究真正的走入了人们的生活之中.近年来,我国就转基因动物的研究也得到了快速的发展,通过对于梅山猪MSTN基因进行编辑而构建的"双肌"表型的新的猪的种群、MSTN基因编辑"超级猪"、生长激素受体基因敲除巴马猪、溶葡萄球菌素转基因克隆牛和人溶菌酶转基因克隆牛、Ipr1基因打靶抗结核克隆牛、肌肉生长抑制素基因敲除的绵羊等转基因动物都有着巨大的产业价值.与转基因动物的育种价值密切相关的是转基因动物的生物安全,所以在我国转基因动物制备及生产均有着严格的规定.随着基因编辑技术飞速发展,转基因动物产业化已经成为不可阻挡的趋势.The Food and Drug Administration of the United States labeled genetically engineered salmon,making transgenic salmon became the first transgenic animal food to enter the global market and people’s daily life.Transgenic animal research in China had great achievements in recent years.Lots of transgenic or gene modified animals were produced,such as Meishan pigs with doublemuscled phenotype,Super-muscly pigs created by small genetic tweak,growth hormone receptor knockout Bama minipig,the cows targeted human lysozyme gene to beta-casein locus using zinc-finger nucleases,the cloned cows with Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus,SP110 knockin cattle with increased resistance to tuberculosis,myostatin knockout sheep and so on,with huge potential industry value.The biosafety issues of transgenic animals are always closed related to their breeding procedure and value and there are very strict regulation and rules in this field in China.With the fast development of gene modification technologies,the industrialization of transgenic animal has become an irresistible trend.

关 键 词：转基因动物 产业化 生物安全 

分 类 号：Q819[生物学—生物工程]