精子获能过程中Zn2+与Mg2+的作用及蛋白质谱变化  

The Functions of Zn2+ and Mg2+ and the Proteomic Changes During Sperm Capacitation

作　　者：李光鹏 LI Guang-peng(The State key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock dinner Mongolia University,Hohhot 010070,China)

机构地区：[1]内蒙古大学省部共建草原家畜生殖调控与繁育国家重点实验室

出　　处：《内蒙古大学学报（自然科学版）》2019年第4期404-413,共10页Journal of Inner Mongolia University：Natural Science Edition

摘　　要：获能是受精的前提条件,只有获能精子才具有超激活运动、发生顶体反应与受精能力.获能期间,精子发生了极为复杂的生理生化反应:质膜通透性与流动性变化、膜内外离子动态变化、蛋白酪氨酸磷酸化与多级信号传导等.尽管发现精子获能现象已近70年,但对其机制的了解远未完成.本文重点介绍Zn^2+与Mg^2+在精子获能中的作用及精子获能前后的蛋白质谱变化.Capacitation is a prerequisite for fertilization.Only the capacitated spermatozoa can undergo hyperactivation,acrosome reaction and subsequently fertilize the oocytes.During capacitation,numerous physiological events occur,including changes of plasm membrane permeability and fluidity,intracellular ion concentrations,activities of enzymes,protein tyrosine phosphorylation,and activated signaling cascades.The capacitation phenomenon was found nearly 70 years ago,however,its mechanisms was far from been fully understood.This article reviewed the latest findings of the functions of Zn^2+ and Mg^2+ and the proteomic changes during sperm capacitation.

关 键 词：超激活 受精 蛋白质组学 体外获能 

分 类 号：Q492.6[生物学—生理学]