猫遗传多态性的研究进展  

Research Progress of Genetic Diversity in Cat( feliscatus)

作　　者：贾松华 岳秉飞[1] JIA Songhua;YUE Bingfei(National Institute for Food and Drug Control,Beijing 100050,China)

机构地区：[1]中国食品药品检定研究院

出　　处：《实验动物科学》2019年第4期81-85,共5页Laboratory Animal Science

基　　金：北京市科技计划“实验用猫地方标准及相关检测技术标准研究”(No.D171100002717001)

摘　　要：实验用猫自19世纪末用于科学研究,现已广泛用于医药研发等各个领域,并作为人类遗传性疾病和感染性疾病的动物模型越来越受重视。猫的质量(尤其是遗传质量)对研究结果的准确性,重复性以及科学性有重要的影响。定期开展遗传质量检测,可有效避免实验用猫的种质退化、遗传漂移,减少实验结果误差等。随着生化标记和DNA分子标记的出现,为了解猫的遗传结构提供了更为简便可靠的方法。本文主要就生化标记和DNA分子标记在研究猫的遗传结构和多态性中的研究现状以及存在的问题进行了探讨。Since the late 19th century,Cats(feliscatus)has been used for scientific research.Now,it is widely applied in various fields of medicine.In addition,cats are gaining more and more attention as animal models of human genetic and infectious diseases.The quality of cats(especially genetic quality)has a significant impact on the accuracy,reproducibility,and scientificity of the findings.It is comparatively vital to carry out genetic quality testing on a regular basis to avoid the deterioration of germplasm,genetic drift and the error of experimental result.With the advent of biochemical markers and DNA molecular markers,a more simple and reliable method for understanding the genetic structure of cats has been provided.In this paper,the current research status and existing problems of biochemical markers and DNA molecular markers in the study of cat genetic structure and polymorphism are discussed.

关 键 词：猫 DNA分子标记 生化标记 遗传多态性 

分 类 号：S829.3[农业科学—畜牧学]