基于复方抑瘤机制的新型纳米中药胶束剂型设计  

Design of novel micellar nano-traditional Chinese medicine formulations based on anti-tumor mechanisms of traditional composition

作　　者：黄若尘 苏永华 苟浩 李威[3] HUANG Ruo-chen;SU Yong-hua;GOU Hao;LI Wei(Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Changhai Traditional Chinese Medicine Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China;Laboratory of Nano Biomedicine,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]上海中医药大学研究生院,上海201203 [2]海军军医大学(第二军医大学)长海中医医院,上海200433 [3]海军军医大学(第二军医大学)纳米医学研究室,上海200433

出　　处：《第二军医大学学报》2019年第8期821-826,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(8167140246,31470964)~~

摘　　要：临床实践证明中药复方具有明显的抗肿瘤作用,深入探讨中药复方有效成分的抗肿瘤作用及其对靶细胞的作用机制,对开发新的纳米中药制剂和临床中西医结合治疗肿瘤有着重要意义。本文概述了中药复方的抗肿瘤研究进展及单味中药的抗肿瘤机制,并在此基础上总结分析了目前传统纳米中药剂型的研究进展,然后以中药紫草中的紫草素为例阐述如何根据单味中药的作用机制,利用纳米材料和纳米自组装技术,围绕临床治疗中的难点设计新型纳米高分子中药剂型。Clinically traditional Chinese medicine(TCM)has been proven to possess obvious anti-tumor effects.It is critical to further explore the effective components and the corresponding mechanism of the TCM against target cells,which also has great significance for developing novel nano-TCM formulations for clinical treatment of tumor.This paper systematically reviews the anti-tumor effects of Chinese herbal compound and the anti-tumor mechanism of single herb.We also summarized the progress in the current traditional nano-TCM preparations.Taking the shikonin in Herba Arnebiae as an example,using the nano-material self-assembly technology,we discussed the design of novel nano-macromolecule TCM formulations while considering the mechanism of single herb and the clinical obstacles.

关 键 词：抗肿瘤药(中药) 复方 纳米技术 纳米中药胶束剂型 

分 类 号：R944.15[医药卫生—药剂学] R289-03[医药卫生—药学]