抗焦虑药辅助治疗突发性聋伴焦虑患者临床疗效的Meta分析  

Meta-analysis of the Clinical Efficacy of Anti-anxiety Drugs in the Treatment of Sudden Deafness with Anxiety

作　　者：李丽[1] 季洁 张小兵[1] Li Li;Ji Jie;Zhang Xiaobing(Department of Otolaryngology,Head and Neck Surgery,The First Hospital of Lanzhou University,Lanzhou,730030,China)

机构地区：[1]兰州大学第一医院耳鼻咽喉头颈外科,兰州730030 [2]兰州市第一人民医院耳鼻咽喉头颈外科

出　　处：《听力学及言语疾病杂志》2019年第5期533-538,共6页Journal of Audiology and Speech Pathology

摘　　要：目的系统性评价抗焦虑药辅助治疗突发性聋(sudden deafness,SD)伴焦虑状态患者的临床疗效。方法通过计算机检索PubMed、Cochrane Library、Web of Science、Embase、万方数据率、中国期刊全文数据库(CNKI)、中国生物医学文献服务系统(SinoMed)和维普数据库(VIP)中以抗焦虑(抑郁)药为辅助干预措施治疗伴焦虑状态突发性聋的随机对照试验(randomized controlled trail,RCT)文献,检索时限均从建库截至2018年6月。按照纳入与排除标准严格筛选文献,采用JADAD评分表的4项条目(随机序列的产生、随机化隐藏、盲法、撤出与退出)评价纳入文献的质量后,使用Stata 12.0软件进行Meta汇总分析。结果最终纳入5个RCT,共653例患者,其中抗焦虑(抑郁)药辅助治疗组(试验组)328例,对照组325例。Meta分析结果显示:辅助治疗后试验组焦虑自评量表(self-rating anxiety scale,SAS)评分[SMD=-2.019,95%CI(-3.094,-0.945),P<0.001]、抑郁自评量表(self-rating depression scale,SDS)评分[SMD=-1.103,95%CI(-1.734,-0.473),P=0.001]、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分[SMD=-1.333,95%CI(-2.160,-0.506),P=0.002]均低于对照组(P<0.01);试验组听力改善总有效率[RR=1.326,95%CI(1.195,1.472),P=0.000]高于对照组(P<0.01)。结论与常规治疗组相比,抗焦虑(抑郁)药辅助治疗可改善突发性聋患者焦虑、抑郁情绪,提高伴焦虑状态突发性聋患者的听力总有效率。Objective To systematically evaluate the clinical efficacy of anti-anxiety drugs in patients of sudden deafness with anxiety.Methods We searched the home and abroad databases for all documents required.The deadline of retrieval was June 2018.The studies were screened according to the inclusion and exclusion criteria.Data were analyzed by Stata 12.0 software.Results Five randomized controlled trials(RCT)with 653 patients were eligible for analysis.Compared with the control group,the adjunctive therapy group significantly reduced the scores of self-rating anxiety scale(SAS)[SMD=-2.019,95%CI(-3.094,-0.945),P0.001],the scores of self-rating depression scale(SDS)[SMD=-1.103,95%CI(-1.734,-0.473),P=0.001]and the scores of Hamilton anxiety scale(HAMA)[SMD=-1.333,95%CI(-2.160,-0.506),P=0.002].The total effective rate of hearing level was significantly improved[RR=1.326,95%CI(1.195,1.472),P0.001].Conclusion Compared with the conventional treatment group,anti-anxiety(depression)drugs adjuvant therapy can improve the total effective rate of patients with sudden onset of anxiety,relieve anxiety,depression and improve clinical efficacy.

关 键 词：突发性聋 焦虑 抑郁 临床疗效 META分析 

分 类 号：R764.43+7[医药卫生—耳鼻咽喉科]