桂枝茯苓胶囊联合地屈孕酮治疗超声子宫内膜回声欠均的异常子宫出血的临床效果  

Clinical effect of Guizhi Fuling Capsules combined with Didrogesterone in the treatment of abnormal uterine bleeding with endometrial uneven echo

作　　者：孙佳琦 朱馥丽 黄欲晓[1] SUN Jiaqi;ZHU Fuli;HUANG Yuxiao(Department of Gynecology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing100080,China)

机构地区：[1]中国中医科学院西苑医院妇科

出　　处：《中国医药导报》2019年第24期103-106,共4页China Medical Herald

基　　金：首都医学发展科研基金项目(2018-2-4174)

摘　　要：目的研究桂枝茯苓胶囊联合地屈孕酮片治疗超声子宫内膜回声欠均异常子宫出血的临床效果。方法收集中国中医科学院西苑医院妇科2018年1~10月收治的60例月经周期第10天内阴式B超示子宫内膜回声欠均的异常子宫出血患者,按其实际用药方式分为观察组及对照组,每组各30例。对照组单纯月经后半周期(第15~25天)给予地屈孕酮口服治疗,观察组月经后半周期口服地屈孕酮(同对照组)并于月经第20天开始加服桂枝茯苓胶囊治疗11 d。记录两组患者的临床疗效及不良反应发生情况。结果治疗3个月后,两组子宫内膜厚度、宫腔稍高回声率及子宫内膜回声不均率均较治疗前显著降低,差异有统计学意义(P<0.05或P<0.01);观察组子宫内膜厚度低于对照组,差异有统计学意义(P<0.05);两组宫腔稍高回声率及子宫内膜回声不均率比较,差异无统计学意义(P>0.05)。两组患者均无明显不良反应发生。结论桂枝茯苓胶囊联合地屈孕酮治疗超声子宫内膜回声欠均,可提高临床治疗效果,改善异常子宫出血情况,且未增加不良反应发生,安全可靠。Objective To study the clinical effect of Guizhi Fuling Capsules combined with desdrogesterone in the treatment of endometrial uneven echo detected by transvaginal ultrasound.Methods From January to October 2018,60 cases of abnormal uterine bleeding with endometrial uneven echo by ultrasound within 10 days of menstruation were collected in the Department of Gynecology of Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine.According to their actual medication method,they were divided into observation group and control group,30 cases in each group.The control group was treated with Dydrogesterone only in the second half of menstruation(from 15th to 25th day),while the observation group was treated with Dydrogesterone in the second half cycle(the same as the control group)and Guizhi Fuling Capsules on the 20th day of menstruation for 11 days.The clinical effects and adverse reactions of the two groups were recorded.Results After 3 months of treatment,the thickness of endometrium,rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo in both groups decreased significantly compared with before treatment,the differences were statistically significant(P<0.05 or P<0.01);the thickness of endometrium in observation group was lower than that of the control group,the difference was statistically significant(P<0.05);There were no statistically significant differences in the rate of slightly higher echo in uterine cavity and the uneven rate of endometrial echo between the two groups(P>0.05).There was no obvious adverse reactions occurred in the two groups.Conclusion Guizhi Fuling Capsules combined with Dydrogesterone in the treatment of endometrial uneven echo by ultrasound can improve the clinical efficacy and abnormal uterine bleeding,without increasing the incidence of adverse reactions,which is safe and reliable.

关 键 词：桂枝茯苓胶囊 地屈孕酮 异常子宫出血 子宫内膜息肉 

分 类 号：R713.4[医药卫生—妇产科学]