硫酸氨基葡萄糖胶囊联合玻璃酸钠注射液治疗膝关节骨性关节炎30例临床观察  

Clinical observation on 30 cases of knee osteoarthritis treated by glucosamine sulfate capsules combined with sodium hyaluronate injection

作　　者：周友良 曾朋[2] 陆小龙[2] 向黎黎 熊辉 ZHOU Youliang;ZENG Peng;LU Xiaolong;XIANG Lili;XIONG Hui(Department of Emergency,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan,410007,China;Department of Orthopedics,the Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan,410005,China;College of TCM,Hunan University of Chinese Medicine,Changsha,Hunan,410208,China)

机构地区：[1]湖南中医药大学第一附属医院急诊科,湖南长沙410007 [2]湖南中医药大学第二附属医院骨伤科,湖南长沙410005 [3]湖南中医药大学中医学院,湖南长沙410208

出　　处：《甘肃中医药大学学报》2019年第4期61-64,共4页Journal of Gansu University of Chinese Medicine

摘　　要：目的观察硫酸氨基葡萄糖胶囊联合玻璃酸钠注射液治疗膝关节骨性关节炎(KOA)的临床疗效。方法将90例KOA患者采用随机数字表法分为对照组1、对照组2和治疗组,各30例。对照组1给予玻璃酸钠注射液关节腔注射,对照组2给予硫酸氨基葡萄糖胶囊口服,治疗组给予硫酸氨基葡萄糖胶囊联合玻璃酸钠注射液治疗,治疗5周后,比较3组的临床疗效、治疗期间的不良反应、治疗结束1个月后的复发率,以及治疗前后的视觉模拟评分法(VAS)评分、膝关节纽约特种外科医院(HSS)评分。结果治疗后3组VAS评分均明显降低,HSS评分均明显升高,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组作用更明显,与对照组1和对照组2治疗后比较差异均有统计学意义(P<0.05);对照组1优良率为56.66%,对照组2为53.33%,治疗组为80.00%,治疗组明显高于对照组1和对照组2,差异均有统计学意义(P<0.05)。对照组1复发率为17.65%,对照组2为25.00%,治疗组为4.17%,治疗组明显低于对照组1和对照组2,差异均有统计学意义(P<0.05)。结论硫酸氨基葡萄糖胶囊联合玻璃酸钠注射液治疗KOA临床疗效显著,且安全性高、复发率低,值得临床推广应用。Objective To observe the clinical efficacy of glucosamine sulfate capsules combined with sodium hyaluronate injection in the treatment of knee osteoarthritis(KOA).Methods Ninety cases of KOA were divided into control group 1,control group 2 and treatment group,with 30 cases in each.Control group 1 was given sodium hyaluronate injection into articular cavity,control group 2 was given glucosamine sulfate capsules orally,and the treatment group was given glucosamine sulfate capsules combined with sodium hyaluronate injection.After treatment for 5 weeks,clinical efficacy,the adverse reactions during the treatment and the recurrence rate after treatment for 1 month,visual analogue scale(VAS)scores,and Hospital for Special Surgery(HSS)scores in New York,of the 3 groups before and after treatment were compared.Results After treatment,VAS scores significantly decreased while HSS scores significantly increased of the 3 groups,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the effects of the treatment group were more significant,and the difference was statistically significant compared with control group 1 and 2 after treatment(P<0.05).The excellent and good rate of control group 1 was 56.66%,that of control group 2 was 53.33%,and that of the treatment group was 80.00%,the treatment group was significantly higher than control group 1 and 2,and the difference was statistically significant(P<0.05).The recurrence rate of control group 1 was 17.65%,that of control group 2 was 25.00%,and that of treatment group was 4.17%,the treatment group was significantly lower than control group 1 and 2,and the difference was statistically significant(P<0.05).Conclusion It has marked clinical efficacy to use glucosamine sulfate capsules combined with sodium hyaluronate injection in the treatment of KOA with high safety and low recurrence rate,which is worthy of clinical promotion and application.

关 键 词：膝关节骨性关节炎 硫酸氨基葡萄糖胶囊 玻璃酸钠注射液 视觉模拟评分法评分 膝关节纽约特种外科医院评分 临床疗效 

分 类 号：R255.6[医药卫生—中医内科学]