基于GrC模型的经颅磁声电刺激对神经元放电活动的影响  

Effect of Transcranial Magnetic-Acoustic Electrical Stimulation on Neuronal Discharge Activity Based on GrC Model

作　　者：张帅[1,2] 高昕宇 周振宇 刘亚泽 徐桂芝[1,2] Zhang Shuai;Gao Xinyu;Zhou Zhenyu;Liu Yaze;Xu Guizhi(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130 China;Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province,Hebei University of Technology,Tianjin 300130 China)

机构地区：[1]省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学),天津300130 [2]河北省电磁场与电器可靠性重点实验室(河北工业大学),天津300130

出　　处：《电工技术学报》2019年第17期3572-3580,共9页Transactions of China Electrotechnical Society

基　　金：国家自然科学基金重点项目（51877069,51737003）;河北省科学研究计划项目（E2015202292,E2015202050,E2017202190）;河北省高校科研重点项目（ZD2017020）;河北省高等学校自然科学青年拔尖人才项目（BJ2016013）资助

摘　　要：经颅磁声电刺激技术(TMAES)是在神经组织中利用静磁场和超声波通过磁声电效应产生感应电流,以实现对神经组织调控的一种无创脑神经刺激手段。对小脑进行适当调控可以改善平衡运动失调等疾病,小脑皮层主要由小脑颗粒细胞构成,建立小脑颗粒细胞模型并对神经调控进行有效模拟具有重要的研究意义和应用价值。通过建立小脑颗粒细胞模型(GrC模型),对比TMAES在不同调制频率下GrC模型神经元放电模式的变化,针对神经元不同位置施加刺激,分析动作电位的传播方向。仿真结果显示,经颅磁声电刺激对GrC模型神经元放电节律具有重要影响。该研究有助于深入理解经颅磁声电刺激的神经作用机理。Transcranial magnetic-acoustical electrical stimulation(TMAES)is a new type of non-invasive brain stimulation in neural tissue that uses static magnetic field and ultrasonic waves to generate current to stimulate nerve tissue through magneto-acoustic electrical effects(also known as Hall effect).The neurological regulation of the cerebellum can improve the balance of movement disorders and other diseases,so the establishment of a model of cerebellar granule cells is of great significance.Firstly,based on the cerebellar granule cell model(GrC model),the changes of the discharge pattern of the GrC model neurons under different modulation frequencies of TMAES were compared.Secondly,the different positions of the neurons are stimulated,and the direction of propagation of the action potential is compared and analyzed.The simulation results show that the TMAES has an important influence on the firing rhythm of the GrC model neurons.The research in this paper is helpful to understand the neural mechanism of TMAES.

关 键 词：经颅磁声电刺激 GRC 模型 神经元 离子通道 

分 类 号：TM12[电气工程—电工理论与新技术]