他克莫司软膏外涂联合308 nm准分子激光照射治疗白癜风的效果观察  

Effect of tacrolimus ointment combined with 308 nm excimer laser irradiation in the treatment of vitiligo

作　　者：刘艳[1] 温广东[2] 马晓蕾[3] 高炳爱[1] LIU Yan;WEN Guang-dong;MA Xiao-lei;GAO Bing-ai(Department of Dermatology,Beijing Aerospace General Hospital,Beijing 100076;Department of Dermatology,Peking University People’s Hospital,Beijing 100044;Department of Dermatology,Peking University International Hospital,Beijing 102206,China)

机构地区：[1]北京航天总医院皮肤科,北京100076 [2]北京大学人民医院皮肤科,北京100044 [3]北京大学国际医院皮肤科,北京102206

出　　处：《蚌埠医学院学报》2019年第8期1048-1050,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨他克莫司软膏外涂联合308 nm准分子激光照射治疗白癜风的临床效果。方法:选取白癜风病人130例,按照随机数表法分为观察组和对照组,各65例。对照组病人采用308 nm准分子激光照射进行治疗,观察组同时加用他克莫司软膏外涂,每天2次。治疗3个月后,比较2组病人的临床疗效和不良反应发生情况,并对2组病人皮损处白细胞介素(IL)-17水平进行测定和比较。结果:观察组病人治疗总有效率为81.54%(53/65),明显高于对照组的60.00%(39/65)(P<0.01)。2组进展期病人的总有效率均高于稳定期(P<0.05);进展期观察组总有效率高于对照组(P<0.05),稳定期2组病人总有效率差异无统计学意义(P>0.05)。治疗前,2组病人IL-17水平差异无统计学意义(P>0.05);治疗后,2组病人的IL-17水平均明显下降(P<0.01),且观察组IL-17水平明显低于对照组(P<0.01)。观察组不良反应发生率为10.77%(7/65),与对照组的7.69%(5/65)差异无统计学意义(P>0.05)。结论:他克莫司软膏外涂联合308 nm准分子激光照射治疗白癜风能够有效提高临床疗效,降低皮损区IL-17水平,且无明显不良反应发生。Objective:To investigate the clinical effects of tacrolimus ointment combined with 308 nm excimer laser irradiation in the treatment of vitiligo.Methods:A total of 130 patients with vitiligo were divided into the observation group and control group according to the random number table method(65 cases each group).The control group was treated with 308 nm excimer laser irradiation,and the observation group was additionally treated with tacrolimus ointment for 2 times/d based on the control group.After 3 months of treatment,the clinical efficacy and adverse reactions between two groups were compared,and the level of IL-17 in the lesions of two groups were measured and compared.Results:The total clinical effective rate in observation group(81.54%,53/65)was higher than that in control group[(60.00%,39/65)(P<0.01).The total effective rate in progressive stage was higher than that in stable stage in two groups(P<0.05),and the differences of the total effective rates in progressive stage and stable stage between two groups were not statistically significant(P>0.05).Before treatment,the difference of the level of IL-17 between two groups was not statistically significant(P>0.05).After treatment,the levels of IL-17 in two groups significantly decreased(P<0.01),and the level of IL-17 in observation group was significantly lower than that in control group(P<0.01).The incidence rates of adverse reaction in observation group and control group were(10.77%,7/65)and 7.69%(5/65),respectively,and the difference of which was not statistically significant(P>0.05).Conclusions:Tacrolimus ointment combined with 308 nm excimer laser irradiation in treating vitiligo can effectively improve the clinical efficacy and reduce the IL-17 level in the lesion area,and has no obvious adverse reaction.

关 键 词：白癜风 他克莫司 准分子激光照射 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]