Development and characterization of a photocurable alginate bioink for three-dimensional bioprinting  

作　　者：H.H.Mishbak Glen Cooper P.J.Bartolo 

机构地区：[1]Department of Biomedical Engineering,School of Engineering,University of Thi-Qar.Thi-Qar,Iraq [2]Manufacturing Group,School of Mechanical,Aerospace and Civil Engineering,The University of Manchester,Manchester,UK

出　　处：《International Journal of Bioprinting》2019年第2期12-26,共15页国际生物打印期刊

摘　　要：Alginate is a biocompatible material suitable for biomedical applications,which can be processed under mild conditions on irradiation.This paper investigates the preparation and the rheological behavior of different pre-polymerized and polymerized alginate methacrylate systems for three-dimensional photopolymerization bioprinting.The effect of the functionalization time on the mechanical,morphological,swelling,and degradation characteristics of cross-linked alginate hydrogel is also discussed.Alginate was chemically-modified with methacrylate groups and different reaction times considered.Photocurable alginate systems were prepared by dissolving functionalized alginate with 0.5-1.5%w/v photoinitiator solutions and cross-linked by ultraviolet light(8 mW/cm2 for 8 minutes).

关 键 词：3D BIOPRINTING ALGINATE HYDROGEL FUNCTIONALIZATION PHOTOPOLYMERIZATION RHEOLOGY 

分 类 号：O63[理学—高分子化学]