松弛素对冠状动脉微循环的影响  

Effects of Relaxin on Coronary Microcirculation

作　　者：张楠[1] 王萍[1] ZHANG Nan;WANG Ping(Heart Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院心血管中心

出　　处：《心血管病学进展》2019年第5期704-708,共5页Advances in Cardiovascular Diseases

基　　金：首都医科大学基础-临床科研合作课题(17JL39);首都医科大学附属北京友谊医院2018院启动基金(yyqdkt2017-1)

摘　　要：近年来发现,松弛素不仅可治疗心力衰竭、心肌纤维化、扩张大动脉血管,而且还可扩张微血管,增加微循环血流灌注,抑制炎症活化,保护血管内皮,抑制内皮-间质转化,减轻缺血再灌注损伤,松弛素可以从多方面改善微循环障碍。现就近年来松弛素在血管、微血管领域的研究进展进行概述,以期为临床治疗冠状动脉微血管疾病提供新的治疗思路,改善冠状动脉微循环障碍患者的生活质量和减少因心绞痛反复就医带来的巨大医疗消费。In recent years,relaxin can not only treat heart failure,cardic fibrosis and dilate large arteries,but also dilate microvessels,increase the microvascular perfusion,inhibit inflammatory activation,protect vascular endothelium,inhibit endothelial-mesenchymal transition,and reduce ischemia-reperfusion injury.In a word,relaxin can improve microvascular dysfunction in several ways.This review summarizes the recent advances of relaxin in the field of vascular and microvascular area,aiming to provide novel therapeutic ideas for coronary microvascular diseases,improve the quality of life of patients with coronary microvascular dysfunction,and reduce the huge medical cost caused by repeated treatment for angina pectoris.

关 键 词：松弛素 微血管 冠状动脉微循环 

分 类 号：R54[医药卫生—心血管疾病]