The effects of trans-resveratrol on insulin resistance,inflammation,and microbiota in men with the metabolic syndrome:A pilot randomized,placebo-controlled clinical trial  

作　　者：Jeanne M.Walker Patricia Eckardt Jose OAleman Joel Correa da Rosa Yupu Liang Tadasu Iizumi Stephane Etheve Martin JBlaser Jan LBreslow Peter RHolt 

机构地区：[1]The Rockefeller University Hospital [2]Laboratory of Biochemical Genetics and Metabolism,Rockefeller University [3]Department of Medicine,New York University School of Medicine,New York [4]DNP R&D Analytics,DSM Nutritional Products LTD,Kaiseraugst,Switzerland

出　　处：《Journal of Clinical & Translational Research》2018年第2期22-35,共14页临床和转化研究

摘　　要：Background and Aim:The metabolic syndrome(MetS)is a pathological condition comprised of abdominal obesity,insulin resistance,hypertension,and hyperlipidemia.It has become a major threat globally,resulting in rapidly increasing rates of diabetes,coronary heart disease,and stroke.The polyphenol resveratrol(RES)is believed to improve glucose homeostasis and insulin resistance by activating sirtuin,which acetylates and coactivates downstream targets and affects glucose and lipid homeostasis in the liver,insulin secretion in the pancreas,and glucose uptake in skeletal muscle.We studied the effects of RES on insulin resistance,glucose homeostasis,and concomitant effects on adipose tissue metabolism and fecal microbiota in insulin-resistant subjects with the MetS.Methods:A total of 28 obese men with the MetS were studied during a 35-day stay in the Rockefeller University Hospital metabolic unit.Subjects were randomized to receive RES 1 g orally twice daily or placebo while kept weight stable and consuming a western-style diet.At baseline,and after 30 days of RES or placebo administration,subjects underwent testing that included a euglycemic,hyperinsulinemic clamp,2-h oral glucose tolerance test(GTT),resting energy expenditure,daily blood pressure monitoring,abdominal adipose tissue biopsy,and fecal and blood collections.Results:RES induced no changes in insulin resistance but reduced the 120-min time point and the area under the curve for glucose concentration in the 2-h GTT.In post-hoc analysis,Caucasian subjects showed a significant improvement in insulin sensitivity and glucose homeostasis after GTT,whereas non-Caucasians showed no similar effects.Levels of fasting plasma RES and its primary metabolite dihydroresveratrol were variable and did not explain the racial differences in glucose homeostasis.RES administration to Caucasian subjects leads to an increase in several taxa including Akkermansia muciniphila.Conclusions:RES 2 g administered orally to obese men with MetS and insulin resistance marginally altered gluc

关 键 词：metabolic syndrome euglycemic hyperinsulinemic clamp insulin resistance RESVERATROL dihydroresveratrol FECAL MICROBIOTA akkermansia muciniphila ADIPOSE tissue gene expression 

分 类 号：R58[医药卫生—内分泌]