基于测量信号的不可逆电穿孔动态过程数值模拟及分析  

Dynamic Numerical Modeling and Analyzing on the Process of Irreversible Electroparation Based on Measurement Signal

作　　者：刘红梅[1] 姚陈果[1] 董守龙[1] 赵亚军[1] 马剑豪 Liu Hongmei;Yao Chenguo;Dong Shoulong;Zhao Yajun;Ma Jianhao(State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing University,Chongqing 400030 China)

机构地区：[1]输配电装备及系统安全与新技术国家重点实验室(重庆大学)

出　　处：《电工技术学报》2019年第18期3732-3740,共9页Transactions of China Electrotechnical Society

基　　金：重庆市研究生科研创新项目(CYB17011);国家自然科学基金(51877022/51807016);中央高校基本科研业务费(2018CDPTCG0001/24)资助项目

摘　　要：近年来,脉冲电场以其独特的生物医学效应及治疗作用在肿瘤的局部微创治疗中展现出广阔的应用前景,运用切实和准确的数值模型实现对脉冲电场引起的电穿孔效应和组织消融效果的有效评估是进一步推广其应用的关键技术和手段。该文提出一种基于低压脉冲测量的方式来获取电穿孔组织消融的动态变化过程,建立考虑时间因素、电场累积效应和热场累积效应的动态电导率数值模型,模拟脉冲施加过程中组织的实时电特性变化。模型计算结果与实验数据的误差在5%以内,具有较好的准确性和可行性,可用于预测不同脉冲参数的脉冲电场作用下组织的电穿孔动态变化,以及电热耦合场的动态时空分布,为后期治疗计划的进一步完善提供切合实际的方法和数据支持。Recently, pulsed electric fields (PEFs) has shown broad prospects in non-thermal minimally invasive treatment of tumors with its unique biomedical and therapeutic effect. Using practical and precise numerical model to effectively estimate the tissue electroporation effect is a regular and key technology to further promote the application of PEFs. This paper proposed a method, which based on low-voltage measurement pulses, to get insight into the dynamic process of tissue ablation by PEFs. Then a dynamic conductivity numerical model, which considered the time, electric field cumulative effects and thermal field cumulative effects was established to simulate the changes tissue electrical characteristics in real-time. The error between the calculated data and the experimental data was less than 5% over a broad range of applied pulse strength, which shows a good feasibility and accuracy. This numerical model could be used to predict dynamic changes in tissue conductivity and the space-time distribution of eletro-thermal coupling field under PEFs with different parameters, which provides method reference and data support for further improvement of treatment planning.

关 键 词：电穿孔 动态电导率 数值模型 不可逆电穿孔 治疗计划 生物电效应 反馈信号 

分 类 号：TM11[电气工程—电工理论与新技术] TM836