丹参+羟苯磺酸钙治疗2型糖尿病早期视网膜病变的临床研究  

Clinical study on Salvia Miltiorrhiza + cal cium dobesilate as the treatment of early retinopathy of type 2 diabetes mellitus

作　　者：王笃亲 关瑞娟[1] 王倩晗 李凌[1] 万李 WANG Du-qin;GUAN Rui-juan;WANG Qian-han;LI Ling;WAN Li(Ophthalmology Department,Qinghai Provin CIal People’s Hospital,Xining,Qinghai Province,810000;Teaching and Research Section of Traditional Chinese Medi CIne,Department of Sports Medicine,Chengdu Sports University,Chengdu,Sichuan Province,610075)

机构地区：[1]青海省人民医院眼科,青海西宁810000 [2]成都体育学院运动医学系中医教研室,四川成都610075

出　　处：《海南医学院学报》2019年第18期1421-1424,1431,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(81473735)~~

摘　　要：目的:研究丹参+羟苯磺酸钙治疗2型糖尿病早期视网膜病变的效果。方法:选择本院收治的非增殖期糖尿病视网膜病变患者,随机分为接受丹参+羟苯磺酸钙治疗的观察组、羟苯磺酸钙治疗的对照组。治疗前及治疗后3个月,进行眼科检查并测量血管瘤体积、黄斑厚度、出血斑面积,采集血清并测定血管新生分子、炎症分子、氧化应激分子的含量。结果:两组治疗后的血管瘤体积、黄斑厚度、出血斑面积以及血清缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)、促红细胞生成素(EPO)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、细胞间黏附分子-1(ICAM-1)、丙二醛(MDA)、晚期蛋白氧化产物(AOPP)含量均明显降低,血清色素上皮衍生因子(PEDF)、血红素加氧酶-1(HO-1)、维生素E(VitE)、总抗氧化力(TAC)含量明显升高且观察组治疗后的血管瘤体积、黄斑厚度、出血斑面积以及血清HIF-1α、VEGF、EPO、IL-1β、TNF-α、ICAM-1、MDA、AOPP含量均明显低于对照组,血清PEDF、HO-1、VitE、TAC含量明显高于对照组。结论:丹参+羟苯磺酸钙治疗2型糖尿病早期视网膜病变能够较单用羟苯磺酸钙更为有效改善病情并抑制血管新生、炎症反应、氧化应激反应。Objective:To study the efficacy of Salvia Miltiorrhiza+calcium dobesilate for the treatment of early retinopathy of type 2 diabetes mellitus.Methods:The patients with non-proliferative diabetic retinopathy admitted to our hospital between August 2016 and February 2018 were chosen and randomly divided into the observation group receiving Salvia Miltiorrhiza+calcium dobesilate and the control group receiving calcium dobesilate.Before treatment and 3 months after treatment,ophthalmologic examination was conducted to measure the hemangioma volume,macular thickness and blood spot area,and serum was collected to measure the contents of angiogenesis molecules,inflammation molecules and oxidative stress molecules.Results:The hemangioma volume,macular thickness and blood spot area as well as serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF),erythropoietin(EPO),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),intercellular adhesion molecule-1(ICAM-1),malondialdehyde(MDA)and advanced oxidation protein product(AOPP)levels of both groups were significantly lower whereas serum pigment epithelium-derived factor(PEDF),heme oxygenase-1(HO-1),vitamin E(VitE)and total antioxidant capacity(TAC)levels were significantly higher after treatment,and the hemangioma volume,macular thickness and blood spot area as well as serum HIF-1α,VEGF,EPO,IL-1β,TNF-α,ICAM-1,MDA and AOPP levels of the observation group after treatment were significantly lower than those of the control group whereas serum PEDF,HO-1,VitE and TAC levels were significantly higher than those of the control group.Conclusion:Salvia Miltiorrhiza+calcium dobesilate treatment of early retinopathy of type 2 diabetes mellitus is more effective than calcium dobesilate alone in improving the condition and inhibiting the angiogenesis,inflammation and oxidative stress.

关 键 词：2型糖尿病 糖尿病视网膜病变 丹参 血管新生 炎症反应 氧化应激反应 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]