血乳酸值动态变化对HBV相关慢加亚急性肝功能衰竭患者近期预后的评估价值  

Value of dynamic changes of blood lactate in evaluating short-term prognosis of patients with HBV-related chronic and subacute liver failure

作　　者：许守连 罗颖敏 周观林 Xu Shoulian;Luo Yingmin;Zhou Guanlin(Department of Liver Disease,Ganzhou Fifth People's Hospital,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市第五人民医院肝病科

出　　处：《当代医学》2019年第27期55-57,共3页Contemporary Medicine

摘　　要：目的探究分析血乳酸值动态变化对HBV相关慢加亚急性肝功能衰竭患者近期预后的评估价值,为今后的临床诊疗工作提供有价值的参考依据。方法选择2017年1月至2018年6月间本院收治的,获得临床确诊的HBV相关慢加亚急性肝功能衰竭患者78例作为研究对象,对其入院后3个月的预后进行随访,将患者按照随访结果分成生存组和死亡组,对两组患者静脉血乳酸、终末期肝病模型评分等进行统计分析。结果本次研究中入组的78例HBV相关慢加亚急性肝功能衰竭患者中,生存组43例,死亡组35例。两组患者临床资料比较差异无统计学意义;生存组患者静脉血乳酸水平较死亡组明显降低(P<0.05);静脉血乳酸对HBV相关慢加亚急性肝功能衰竭患者3个月死亡的预测灵敏度、特异性分别为80%、68%,稍低于终末期肝病模型评分系统,差异无统计学意义。结论静脉血乳酸值与HBV相关慢加亚急性肝功能衰竭患者预后存在十分密切的联系,对于死亡预后具有显著临床价值,值得关注。Objective To analyze the value of dynamic changes of blood lactate level in the evaluation of short-term prognosis of patients with HBV-related slow and subacute liver failure,and provide valuable reference for future clinical diagnosis and treatment.Methods A total of 78 patients with clinically confirmed HBV-related chronic and subacute liver failure who were admitted to our hospital from January 2017 to June 2018 were enrolled.The prognosis was followed up for 3 months after admission.The patients were divided into survival group and death group according to the follow-up results.The venous blood lactate and end-stage liver disease model scores of the two groups were statistically analyzed.Results Of the 78 patients with HBV-related chronic and subacute liver failure who were enrolled in the study,43 patients in the survival group and 35 patients in the death group.There was no significant difference in the general data between the two groups.The venous blood lactate level in the survival group was significantly lower than that in the death group(P<0.05).The prediction of venous blood lactate on the three-month death of patients with HBV-related slow and subacute liver failure The sensitivity and specificity were 80%and 68%,respectively,which were slightly lower than the end-stage liver disease model scoring system.The difference was not statistically significant.Conclusion The venous blood lactate value is closely related to the prognosis of patients with HBV-related slow and subacute liver failure.It has significant clinical value for death prognosis and is worthy of attention.

关 键 词：血乳酸 终末期肝病模型评分 慢加亚急性肝功能衰竭 HBV 

分 类 号：R51[医药卫生—内科学]