相转移催化合成唑酮的动力学研究  

Kinetics of phase transfer catalytic synthesis of azolone

作　　者：牛亚宾 计海峰 王卫东 Niu Yabin;Ji Haifeng;Wang Weidong(Institute of Petrochemical Engineering,Jilin Institute of Chemical Technology,Jilin Jilin 132022,China;School of Chemical Engineering,Dalian University of Technology,Dalian Liaoning 116024,China)

机构地区：[1]吉林化工学院石油化工学院,吉林吉林132022 [2]大连理工大学化工学院,辽宁大连116024

出　　处：《石油化工》2019年第9期921-925,共5页Petrochemical Technology

基　　金：吉林省科技攻关计划项目（20170204009GX）;吉林省产学研引导基金项目（20170342）;吉林化工学院重大项目（2015021）

摘　　要：以1-氯-1-氯乙酰基环丙烷与1,2,4-三氮唑为原料,在相转移催化剂条件下,对制备1-(1-氯环丙基)-2-(1,2,4-三唑基)乙酮的反应动力学进行了研究,考察了反应温度对收率的影响,建立了反应动力学模型,并对动力学参数的有效性进行验证。实验结果表明,温度为323~328 K时,1-氯-1-氯乙酰基环丙烷与1,2,4-三氮唑的反应为二级反应,表观活化能为46.63 kJ/mol,指数前因子为3.67×107 L/(mol·h);通过比较验证,动力学模型计算值与实验值接近,为合成工艺的优化设计提供了依据。With 1-chloro-1-chloroacetyl cyclopropane and 1,2,4-triazole as raw materials,the reaction kinetics of the preparation of 1-(1-chlorocyclopropyl)-2-(1,2,4-triazolyl)ethanone was studied under the condition of phase transfer catalyst.The effect of reaction temperature on the yield was investigated,the reaction kinetics model was established,and the validity of kinetic parameters was verified.The results showed that the reaction of 1-chloro-1-chloroacetylcyclopropane with 1,2,4-triazole was a secondary reaction at a temperature of 323-328 K,and the apparent activation energy was 46.63 kJ/mol,pre-exponential factor is 3.67×107 L/(mol·h).By comparison,the calculated values of the kinetic model are close to the experimental values,which provides a basis for optimum design of synthesis process.

关 键 词：1-(1-氯环丙基)-2-(1 2 4-三唑基)乙酮 动力学 1 2 4-三氮唑 

分 类 号：TQ031.2[化学工程]