丙型肝炎患者HCV RNA载量与HCV-cAg及SOD、FFA相关性分析  

Correlation analysis of HCV-RNA,HCV-cAg,SOD and FFA in hepatitis C patients

作　　者：方伟祯[1] 古文深 房绮梅 曾无艺 丁睿[1] 段朝晖[1] FANG Weizhen;GU Wenshen;FANG Qimei;ZENG Wuyi;DING Rui;DUAN Chaohui(Laboratory Department,Sun Yat?Sen Memorial Hospital of Sun Yet?Sen University,Guangzhou,Guang?dong,China,510120;Guangzhou Medical University,Guangzhou,Guangdong,China,511436)

机构地区：[1]中山大学孙逸仙纪念医院检验科,广东 广州 510120 [2]广州医科大学,广东 广州 511436

出　　处：《分子诊断与治疗杂志》2019年第5期414-417,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广东省自然科学基金(2014A030313070)

摘　　要：目的探究丙型病毒性肝炎患者血清中丙肝病毒RNA(HCV RNA)载量与丙型肝炎核心抗原(HCV?cAg)及超氧化物歧化酶(SOD)、游离脂肪酸(FFA)的相关性。方法对2015年1月至2019年2月105例HCV RNA定量检测为阳性的临床标本,同时检测其HCV?cAg及SOD、FFA的含量。结果HCV RNA载量与HCV?cAg、SOD、FFA水平有显著相关性,随着患者体内HCV RNA载量的升高,HCV?cAg阳性率也随之升高,差异有统计学意义(P<0.05),两者呈正相关;HCV RNA载量不同组间SOD水平比较差异有统计学意义(P<0.05),SOD水平随着患者体内HCV?RNA载量的升高而降低,两者呈负相关关系;低、中载量组间FFA水平比较差异无统计学意义(P>0.05),而均与高载量组比较差异有统计学意义(P<0.05)。结论HCV?cAg与HCV RNA有良好的相关性,出现时间早且适合基层推广,SOD和FFA在一定程度上可以反映病情进展情况,联合检测在丙型肝炎的早期诊断和监测治疗效果上有重要的临床意义。Objective To investigate the correlation between hepatitis C virus RNA(HCV RNA)load and hepatitis C core antigen(HCV?cAg),superoxide dismutase(SOD)and free fatty acid(FFA)in patients with hepatitis C virus.Methods 105 cases of positive HCV RNA quantitative test were collected from January 2015 to February 2019,and the levels of HCV?cAg,SOD and FFA were also detected.Results The HCV RNA load was significantly correlated with the levels of HCV?cAg,SOD and FFA.The HCV?cAg positive rate was increased with the HCV RNA(P<0.05);The SOD level was negative association with the HCV RNA(P<0.05);though there was no significant difference of the HCV RNA load between the low and medium level of FFA groups(P>0.05),however,there was a statistically significant difference between high?load group and the remaining 2 groups(P<0.05).Conclusion HCV?cAg has a good correlation with HCV RNA.The level of SOD and FFA could reflect the progress of the disease.These combined detection methods have important clinical significance in the early diagnosis and monitoring of hepatitis C.

关 键 词：丙型肝炎 HCV-RNA 超氧化物歧化酶 游离脂肪酸 

分 类 号：R51[医药卫生—内科学]