Animal modeling in bone research—Should we follow the White Rabbit?  

作　　者：Aline Schafrum Macedo Caroline Cezaretti Feitosa Fernando Yoiti Kitamura Kawamoto Paulo Vinicius Tertuliano Marinho Isis dos Santos Dal‐Bo Bianca Fiuza Monteiro Leonardo Prado Thales Bregadioli Gabriel Antonio Covino Diamante Cassio Ricardo Auada Ferrigno 

机构地区：[1]Department of Veterinary Surgery,School of Veterinary Medicine and Animal Sciences,University of Sao Paulo,USP,Sao Paulo,SP,Brazil [2]Department of Veterinary Surgery,School of Agricultural and Veterinarian Sciences,Sao Paulo State University,UNESP,Jaboticabal,SP,Brazil [3]Department of Veterinary Surgery,Federal Institute of Education,Science,and Technology of Southern Minas Gerais,IFSULDEMINAS,Muzambinho,MG,Brazil

出　　处：《Animal Models and Experimental Medicine》2019年第3期162-168,共7页动物模型与实验医学（英文）

摘　　要：Animal models are live subjects applied to translational research.They provide insights into human diseases and enhance biomedical knowledge.Livestock development has favored the pace of human social development over millennia.Today's society is more aware of animal welfare than past generations.The general public has marked objections to animal research and many species are falling into disuse.The search for an ideal methodology to replace animal use is on,but animal modeling still holds great importance to human health.Bone research,in particular,has unmet requirements that in vitro technologies cannot fully address.Standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models.Our aim here is to provide a broad overview of animal modeling and its ethical implications,followed by a narrower focus on bone research and the role rabbits are playing in the current scenario.Animal models are live subjects applied to translational research. They provide insights into human diseases and enhance biomedical knowledge. Livestock development has favored the pace of human social development over millennia. Today’s society is more aware of animal welfare than past generations. The general public has marked objections to animal research and many species are falling into disuse. The search for an ideal methodology to replace animal use is on, but animal modeling still holds great importance to human health. Bone research, in particular, has unmet requirements that in vitro technologies cannot fully address. Standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models. Our aim here is to provide a broad overview of animal modeling and its ethical implications, followed by a narrower focus on bone research and the role rabbits are playing in the current scenario.

关 键 词：animal experimentation bone density LAGOMORPHA translational medical research 

分 类 号：R33[医药卫生—人体生理学]