Spontaneous pancreatic undifferentiated pleomorphic sarcoma in a laboratory rat: A case report  

作　　者：Petros Ypsilantis Soultana Meditskou Maria Lambropoulou Theodora Papamitsou Constantinos Simopoulos 

机构地区：[1]Laboratory of Experimental Surgery and Surgical Research,School of Medicine,Democritus University of Thrace,Alexandroupolis,Greece [2]Laboratory of Histology and Embryology,Aristotle University of Thessaloniki,Thessaloniki,Greece [3]Laboratory of Histology and Embryology,School of Medicine,Democritus University of Thrace,Alexandroupolis,Greece

出　　处：《Animal Models and Experimental Medicine》2019年第3期222-225,共4页动物模型与实验医学（英文）

摘　　要：We present a case of spontaneous undifferentiated/unclassified sarcoma,of a pleomorphic subtype formerly known as malignant fibrous histiocytoma(UPS/MFH),arising from the pancreas of a laboratory rat.The mass was excised after laparotomy from a 6‐month‐old female laboratory Wistar rat.It presented a giant multilobulated mass of irregular shape,which had arisen from the pancreas and occupied almost the entire peritoneal cavity.Histologically the tumor was characterized by a highly variable morphological pattern,with frequent transitions from storiform to pleomorphic areas.An extensive immunohistochemical examination revealed no specific lines of differentiation.Immunohistochemical positivity was observed only to MIB‐1(high Ki‐67 proliferation index),vimentin and CD68 antibodies.The diagnosis was compatible with UPS/MFH.To the best of our knowledge,the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.We present a case of spontaneous undifferentiated/unclassified sarcoma, of a pleomorphic subtype formerly known as malignant fibrous histiocytoma(UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly variable morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1(high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compatible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.

关 键 词：malignant FIBROUS HISTIOCYTOMA PANCREAS PLEOMORPHIC rat UNDIFFERENTIATED SARCOMA 

分 类 号：R73[医药卫生—肿瘤]