新生血管性青光眼患者房水和血浆中PlGF IL-1β和TGF-β2的测定及意义  

Determinations and Significances of PlGF, IL-1β and TGF-β2 in Aqueous Humor and Plasma of Patients with Neovascular Glaucoma

作　　者：刘雪莲[1] 吴桂花[1] 张燕[1] LIU Xuelian;WU Guihua;ZHANG Yan(Department of Ophthalmology,Hechuan District People's Hospital of Chongqing,Chongqing 401520,China)

机构地区：[1]重庆市合川区人民医院眼科

出　　处：《河北医学》2019年第9期1512-1515,共4页Hebei Medicine

基　　金：重庆市卫生计生委科研基金项目,(编号:2017MSXM179)

摘　　要：目的:检测新生血管性青光眼(NVG)患者房水和血浆中胎盘生长因子(PlGF)PlGF、白细胞介素-1β(IL-1β)、和转化生长因子(TGF-β2)水平,并分析房水和血浆中PlGF、IL-1β和TGF-β2水平的关系。方法:选取2016年4月至2018年9月本院确诊为NVG的患者42例,共42只眼,选取同期年龄相关性白内障(ARC)患者50例(50眼)作为对照组,采用酶联免疫吸附法(ELISA)检测房水和血清中PlGF、IL-1β和TGF-β2水平。结果:NVG组患者房水和血清中PlGF、IL-1β、TGF-β2水平显著高于ARC组患者(P<0.05);NVG组患者房水较血清中PlGF、TGF-β2水平显著升高(P<0.05);ARC组患者房水较血清中PlGF、TGF-β2水平无显著变化(P>0.05);两组患者房水较血清中IL-1β水平均显著升高(P<0.05)。经Pearson检验,NVG患者房水和血清中PlGF、IL-1β、TGF-β2水平均正相关(P<0.05)。结论:NVG组患者房水和血清中PlGF、IL-1β、TGF-β2水平显著高于对照组,可能与NVG疾病发生有关。Objective:To detect the levels of placental growth factor(PlGF),interleukin-1β(IL-1β),and transforming growth factor(TGF-β2)in aqueous humor and plasma of patients with neovascular glaucoma(NVG),and to explore the relationships between the levels of PlGF,IL-1βand TGF-β2 in aqueous humor and plasma.Methods 42 patients(42 eyes)diagnosed as NVG in our hospital from April 2016 to September 2018 were selected,50 cases(50 eyes)of patients with age-related cataract(ARC)were selected as control group,enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of PlGF,IL-1βand TGF-β2 in aqueous humor and serum.Results:The levels of PlGF,IL-1βand TGF-β2 in aqueous humor and serum of patients in group NVG were significantly higher than those of ARC patients(P<0.05);the levels of PlGF and TGF-β2 in aqueous humor were significantly higher than those in serum in group NVG(P<0.05);there was no significant change in the levels of PlGF and TGF-β2 between aqueous humor with serum of ARC patients(P>0.05);the level of IL-1βin the two groups was significantly higher than that in the serum(P<0.05).Pearson test showed that the levels of PlGF,IL-1βand TGF-β2 in aqueous humor and serum of NVG patients were positively correlated(P<0.05).Conclusion:The levels of PlGF,IL-1βand TGF-β2 in aqueous humor and serum of patients in group NVG are significantly higher than those in control group,it may be related to NVG disease.

关 键 词：新生血管性青光眼 房水 血浆 胎盘生长因子 转化生长因子Β2 白细胞介素1β 

分 类 号：R71[医药卫生—妇产科学]