匹维溴铵联合依帕司他甲钴胺治疗糖尿病性肠病的临床研究  

Clinical Study on Diabetic Intestinal Disease Treated by Pinaverium Bromide Combined with Epalrestat and Methylcobalamin

作　　者：杨俐[1] 辛薇[1] 崔硕[1] 王迪 郭莹辉[1] 杨志霞[1] YANG Li;XIN Wei;CUI Shuo(Langfang People's Hospital,Hebe Langfang 065000,China)

机构地区：[1]河北省廊坊市人民医院

出　　处：《河北医学》2019年第9期1532-1535,共4页Hebei Medicine

基　　金：河北省自然科学基金资助项目,(编号:H2014206177);河北省廊坊市科技支撑计划项目,(编号:2017013139)

摘　　要：目的:探讨匹维溴铵联合依帕司他、甲钴胺治疗糖尿病性肠病的疗效及可行机制。方法:选择在廊坊市人民医院门诊及住院治疗的2型糖尿病并发糖尿病性肠病的患者208例,将208例符合上述标准的门诊及住院患者分成两组,观察组及治疗组各104例,两组患者均给予胰岛素控制血糖,观察前停用影响胃肠道动力的药物。观察组加用甲钴胺0.5微克3/d口服;治疗组在原有甲钴胺0.5微克3/d口服的基础上,联合匹维溴铵50mg 3/d及依帕司他50mg3/d口服治疗,连续服用3个月。结果:两组患者临床资料的对比差异不具有统计学意义(P>0.05)。两组患者疗效对比,治疗组总有效率明显高于观察组,差异具有统计学意义(P<0.05)。两组患者治疗后腹泻情况及便秘情况得分对比,治疗组治疗后的得分明显低于观察组治疗后得分,差异具有统计学意义(P<0.05)。结论:匹维溴铵联合依帕司他、甲钴胺治疗糖尿病性肠病疗效显著,值得推广应用。Objective:To investigate the efficacy and feasible mechanism of pinaverium bromide combined with epalrestat and mecobalamin in the treatment of diabetic bowel disease.Methods:A total of 208 patients with type 2 diabetes mellitus complicated with diabetic bowel disease were selected in outpatient and inpatient treatment in Langfang People’s Hospital.208 outpatients and inpatients meeting the above criteria were randomly divided into two groups.Each group received 104 patients in the treatment group.In both groups,insulin was administered to control blood glucose,and drugs that affect gastrointestinal motility were discontinued before observation.The observation group was treated with methylcobalamin 0.5μg 3/day orally;the treatment group was on the basis of 0.5μg of original mecobalamin 3/day orally,combined with pinaverium bromide 50 mg 3/day and epalrestat 50 mg 3/Oral treatment daily for 3 months.Results:There was no significant difference in clinical data between the two groups(P>0.05).The efficacy of the two groups was significantly higher than that of the observation group.The difference was statistically significant(P<0.05).The scores of diarrhea and constipation and after treatment were compared between the two groups.The scores after treatment in the treatment group were significantly lower than those in the observation group after treatment.The differences were statistically significant.Significance(P<0.05).Conclusion:Pinaverium bromide combined with Epalrestat and Methylcobalamin have significant curative effects on diabetic bowel disease,which is worthy of popularization and application.

关 键 词：糖尿病性肠病 匹维溴铵 依帕司他 甲钴胺 

分 类 号：R47[医药卫生—护理学]