滋阴补肾法治疗脾肾阳虚型多囊卵巢综合征对卵泡发育影响  

The influence of traditional Chinese medicine formula (Ziyin bushen) for treating women with polycystic ovary syndrome on their follicular growth

作　　者：张巍 许利 ZHANG Wei;XU Li(Bengbu First People's Hospital,Clinical College Affiliated to Bengbu Medical University,Anhui Province,233000)

机构地区：[1]蚌埠医学院附属临床学院蚌埠市第一人民医院

出　　处：《中国计划生育学杂志》2019年第9期1146-1149,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨滋阴补肾法治疗脾肾阳虚型多囊卵巢综合征效果及对卵泡发育的影响。方法:选择2015年7月—2017年7月本院收治的68例脾肾阳虚型多囊卵巢综合征患者,随机数表法分为观察组(n=35)和对照组(n=33),观察组采用滋阴补肾组方治疗,对照组采用克罗米芬治疗,比较两组临床疗效、血清促卵泡生成素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E 2)、胰岛素(INS)、血清血管内皮生长因子(VEGF)、内皮抑素(ES)、卵巢间质搏动指数(PI)、阻力指数(RI)、收缩期峰值血流速度(PSV)及收缩期峰值流速/舒张末期血流速度(S/D)、卵泡液过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPx)、谷氨酸半胱氨酸连接酶(Gcl c)、总抗氧化能力(TAC)、超氧化物歧化酶(SOD)水平。结果:治疗后,观察组临床疗效总有效率(94.3%)高于对照组(72.7%),两组血清VEGF、ES、PI、RI、PSV、S/D、FSH、LH、T、E 2、INS水平均下降,且观察组低于对照组(均P<0.05);两组卵泡液TAC、SOD、CAT、GPx、Gc l c水平均上升,且观察组高于对照组(P<0.05)。结论:滋阴补肾法治疗脾肾阳虚型多囊卵巢综合征效果显著,可有效改善患者卵泡发育及卵巢间质血流动力学水平。Objective:To explore the curative efficacy of traditional Chinese medicine formula(Ziyin buseng)for treating women with polycystic ovary syndrome(PCOS),and to study its influence on the follicular growth of women.Methods:68 women with PCOS were selected and were divided into observation group(n=35)and control group(n=33)by random number table from July 2015 to July 2017.The women in the observation group were treated by traditional Chinese medicine formula(Ziyin buseng),while the women in the control group were treated by clomiphene.The clinical curative effect,the serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),estradiol(E 2),insulin(INS),vascular endothelial growth factor(VEGF),endothelial inhibition(ES),follicular fluid catalase(CAT),glutathione peroxidase(GPx),glutamic acid cysteine ligase(Gcl c),total antioxidant capacity(TAC),and superoxide dismutase(SOD),and ovarian stroma pulsation index(PI),resistance index(RI),systolic peak flow velocity(PSV)and systolic/diastolic peak flow velocity at the end of blood flow velocity(S/D)of women were compared between the two groups.Results:After treatment,the total effective rate of women(94.3%)in the observation group was significant higher than that(72.7%)of women in the control group.Serum levels of VEGF,ES,PI,RI,PSV,S/D,FSH,LH,T,E 2 and INS of all women in the two groups had significantly decreased,and those of women in the observation group were significant lower than those of women in the control group(P<0.05).The levels of TAC,SOD,CAT,GPx and Gc lc in follicular fluid of all women had significantly increased,and those of women in the observation group were significant higher than those of women in the control group(P<0.05).Conclusion:Traditional Chinese medicine formula(Ziyin buseng)for treating women with PCOS and Traditional Chinese medicine Shenyangxu has good efficacy, which can effectively promote the follicular growth and improve the hemodynamic situation of the ovarian interstitium of women.

关 键 词：多囊卵巢综合征 脾肾阳虚型 滋阴补肾法 卵泡发育 

分 类 号：R71[医药卫生—妇产科学]