妊娠糖尿病患者脂肪组织中IRS-1、IRS-2、Omentin-1表达与胰岛素抵抗  

Expression of IRS1, IRS2 and omentin 1 in adipose tissue of women with gestational diabetes mellitus and their relevant to insulin resistance

作　　者：杨敏 张静 赵喜花 YANG Min;ZHANG Jing;ZHAO Xihua(People's Hospital of Ci County,Hebei Province,056500)

机构地区：[1]河北省磁县人民医院

出　　处：《中国计划生育学杂志》2019年第9期1159-1162,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠糖尿病患者脂肪组织中胰岛素受体底物1(IRS 1)、IRS 2及血清网膜素1(Omentin 1)的表达特征,分析与胰岛素抵抗的相关性。方法:选取50例妊娠糖尿病患者和50例正常孕妇分别纳入观察组和对照组。产前测定血清Omentin 1水平、空腹胰岛素(FIns)、空腹葡萄糖(FPG)水平,计算胰岛素抵抗指数(HOMA IR)。分娩过程中采集大网膜脂肪组织,检测IRS 1、IRS 2蛋白表达水平。结果:观察组FPG、FIns、HOMA IR水平均高于对照组,Omentin 1水平低于对照组(P<0.05),脂肪组织中IRS 1、IRS 2蛋白表达水平均低于对照组(P<0.05)。HOMA IR与Omentin 1、IRS 1、IRS 2均呈负相关(P<0.05),Omentin 1与IRS 1、IRS 2均呈正相关(P<0.05)。结论:血清Omentin 1表达可激活胰岛素受体后信号传导通路,增加胰岛素敏感性,血清Omentin 1及脂肪组织中IRS 1、IRS 2表达降低均使胰岛素抵抗进一步加剧。Objective:To investigate the expression of insulin receptor substrate(IRS)1,IRS 2 in adipose tissue and serum omenin 1 of women with gestational diabetes mellitus(GDM),and to analyze their correlation with insulin resistance.Methods:50 pregnant women with GDM were included in the observation group and 50 health pregnant women were selected in the control group.The levels of omentin 1,FINS,FPG of all included women were measured before delivery,and HOMA IR of women were calculated.The adipose tissue of women was collected for detecting the expression of IRS1 and IRS2 during delivery.Results:The levels of FPG and FINS,and value of HOMA IR of women in the observation group were significant higher than those of women in the control group,and the level of omentin 1 was significant lower than that of women in the control group(P<0.05).The levels of IRS 1 and IRS 2 in adipose tissue of women in the observation group were significant lower than those of women in the control group(P<0.05).The value of HOMA IR was negatively correlated with levels of omentin 1,IRS 1 and IRS 2(P<0.05),while omentin 1 level was positively correlated with levels of IRS1 and IRS2(P<0.05).Conclusion:Serum Omentin 1 expression can activate signal transduction pathway back insulin receptor and can increase insulin sensitivity.The decreasing of expressions of serum omentin 1 and IRS 1 and IRS 2 in adipose tissue can further aggravate insulin resistance.

关 键 词：妊娠期糖尿病 脂肪组织:胰岛素受体底物 网膜素1 胰岛素抵抗 

分 类 号：R58[医药卫生—内分泌]