2017年山西省婴幼儿流行性脑脊髓膜炎病例病原学分析  

Etiology of meningococcal meningitis cases in infants in Shanxi, 2017

作　　者：韩吉婷 杨红霞[1] 王洋[1] 杨婷婷[1] 张秋香[1] 姚素霞[1] 郝瑞娥[1] 朱兵清[2] Han Jiting;Yang Hongxia;Wang Yang;Yang Tingting;Zhang Qiuxiang;Yao Suxia;Hao Ruie;Zhu Bingqing(Shanxi Provincial Center for Disease Control and Prevention,Taiyuan 030012,Shanxi,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]山西省疾病预防控制中心,山西太原030012 [2]中国疾病预防控制中心传染病预防控制所,北京102206

出　　处：《疾病监测》2019年第8期697-700,共4页Disease Surveillance

基　　金：山西省卫生计生委科研课题(No.2018GW02)~~

摘　　要：目的分析2017年山西省由B群脑膜炎奈瑟菌引起的3例婴幼儿流行性脑脊髓膜炎(流脑)病例病原学特征。方法收集3例婴幼儿流脑病例的临床流行病学资料,采集病例脑脊液和血液标本进行脑膜炎奈瑟菌培养、分离、鉴定和血清分群,采用多位点序列分型(MLST)方法进行分子分型,药敏E-test试纸条法检测抗生素敏感性。结果 3例B群流脑病例发病月龄分别为12 d、5月龄和8月龄,符合化脓性脑膜炎症状,脑脊液标本均分离培养出3株B群脑膜炎奈瑟菌。MLST序列分型分析显示,2株菌为ST-5664(CC4821),1株为ST-5662。3株B群菌株均对环丙沙星、左氧氟沙星和复方新诺明等药物耐药。结论山西省首次从病例标本中分离到B群脑膜炎奈瑟菌,3例B群流脑病例均为婴幼儿发病,且主要基因型属于CC4821。Objective To analyze the etiologic characteristics of three meningococcal meningitis cases in infants in Shanxi province in 2017. Methods Epidemiological data and clinical samples of suspected meningococcal meningitis cases were collected. Cerebrospinal fluid and blood specimens were used for the culture, isolation, identification of Neisseria meningitidis.Serogroup identification of N. meningitidis isolates were confirmed by slide agglutination test with serogroup B antiserum.Multi locus sequence typing(MLST) was used for molecular typing and E-test method was used for antimicrobial resistance test. Results Three meningococcal meningitis cases were aged 12 d, 5 months and 8 months, respectively, showing symptoms of purulent meningitis. Three N. meningitidis B strains were isolated, in which two belonged to ST-5664(Clonal Complex 4821, CC4821) and one belonged to ST-5662 indicated by MLST. All the serogroup B isolates were resistant to ciprofloxacin, levofloxacin and sulfonamides. Conclusion Three meningococcal meningitis cases caused by N. meningitidis B occurred in Shanxi in 2017, the cases were all infants. It was the first time to isolate N. meningitidis B from case specimens in Shanxi, the major sequence type of the strains belonged to CC4821.

关 键 词：流行性脑脊髓膜炎 B群 脑膜炎奈瑟菌 血清群 

分 类 号：R512.2[医药卫生—内科学]