2010-2018年安徽省吸毒人群丙型肝炎病毒感染状况及危险行为分析  

Hepatitis C virus infection status and risk behaviors of drug users in Anhui, 2010–2018

作　　者：沈月兰[1] 程晓莉[1] 姚晖[2] 艾平[3] 王祥[4] 朱宏斌[5] 丁心平[6] 岳嵚 苏斌[1] Shen Yuelan;Cheng Xiaoli;Yao Hui;Ai Ping;Wang Xiang;Zhu Hongbin;Ding Xinping;Yue Qin;Su Bin(Anhui Provincial Center for Disease Control and Prevention,Hefei 230000,Anhui,China;Hefei Municipal Center for Disease Control and Prevention,Hefei 230000,Anhui,China;Xuancheng Prefectural Center for Disease Control and Prevention,Xuancheng 242000,Anhui,China;Bengbu Prefectural Center for Disease Control and Prevention,Bengbu 233000,Anhui,China;Ma′anshan Prefectural Center for Disease Control and Prevention,Ma'anshan 243000,Anhui,China;Fuyang Prefectural Center for Disease Control and Prevention,Fuyang 236000,Anhui,China;Huainan Prefectural Center for Disease Control and Prevention,Huainan 232000,Anhui,China)

机构地区：[1]安徽省疾病预防控制中心,安徽合肥230000 [2]合肥市疾病预防控制中心,安徽合肥230000 [3]宣城市疾病预防控制中心,安徽宣城242000 [4]蚌埠市疾病预防控制中心,安徽蚌埠233000 [5]马鞍山市疾病预防控制中心,安徽马鞍山243000 [6]阜阳市疾病预防控制中心,安徽阜阳236000 [7]淮南市疾病预防控制中心,安徽淮南232000

出　　处：《疾病监测》2019年第8期710-714,共5页Disease Surveillance

摘　　要：目的了解安徽省吸毒人群丙型肝炎病毒(HCV)感染状况和危险行为特征,为制定预防吸毒人员感染HCV措施提供依据。方法对2010-2018年安徽省吸毒人员进行问卷调查和血清学检测,采用趋势性检验分析HCV抗体阳性率和多元logistic回归分析HCV感染的影响因素。结果 2010-2018年安徽省共调查18 925名吸毒者,吸毒人群HCV抗体阳性率分别为35.2%、34.9%、39.1%、30.4%、22.5%、20.1%、20.5%、18.6%和19.1%(趋势χ^2=458.635,P<0.001),多元logistic回归分析显示来源于社区(a OR=1.310,95%CI:1.074~1.597);美沙酮门诊(a OR=3.182,95%CI:1.434~7.062);20^(a OR=2.246,95%CI:1.134^4.450)、30^(a OR=5.283,95%CI:2.669^10.458)、40^(a OR=7.158,95%CI:3.565^14.375)、50^(a OR=3.125,95%CI:1.205^8.102);在婚(a OR=1.708,95%CI:1.296~2.252)、离异或丧偶(a OR=1.818,95%CI:1.354~2.442);注射吸毒史(a OR=5.370,95%CI:4.239~6.804)和最近一年商业性行为中有时使用安全套(a OR=1.254,95%CI:1.037~1.517)和从未使用安全套(a OR=1.282,95%CI:1.021~1.610)是吸毒者感染HCV的高危因素。结论安徽省吸毒人群HCV感染率较高,整体呈下降趋势,需采取有效措施减少感染HCV的危险行为。Objective To understand the hepatitis C virus(HCV) infection status and risk behavior characteristics of drug users in Anhui province, and provide evidence for the establishment of measures to prevent HCV infection in drug users.Methods Questionnaire survey and serological test were conducted for drug users in Anhui during 2010–2018, trend test was used to analyze the positive rate of HCV antibody and multivariate logistic regression analysis was done to identify the risk factors for HCV infection. Results A total of 18 925 drug users were investigated in Anhui from 2010 to 2018. The aanual positive rate of HCV antibody in drug users were 35.2%, 34.9%, 39.1%, 30.4%, 22.5%, 20.1%, 20.5%, 18.6% and 19.1%respectively(trend χ^2=458.635, P<0.001). Multivariate logistic regression analysis showed that living in community(a OR=1.310, 95%CI: 1.074-1.597), methadone treatment(a OR=3.182, 95%CI: 1.434-7.062), 20-years old(a OR=2.246,95% CI: 1.134-4.450), 30-years old(a OR=5.283, 95%CI: 2.669-10.458), 40-years old(a OR=7.158, 95%CI:3.565-14.375) and 50-years old(a OR=3.125, 95%CI: 1.205-8.102), married(a OR=1.708, 95%CI: 1.296-2.252), divorced or widowed(a OR=1.818, 95%CI: 1.354-2.442), history of injecting drug use(a OR=5.370, 95%CI: 4.239-6.804), seldom condom use in commercial sex in the past year(a OR=1.254, 95%CI: 1.037-1.517) and never using condom(a OR=1.282,95%CI: 1.021-1.610) were high risk factors for HCV infection in drug users. Conclusion The infection rate of HCV in the drug users in Anhui was high, but showed a downward trend. Therefore, effective measures should be taken to reduce the risk of HCV infection in drug users.

关 键 词：吸毒人群 丙型肝炎病毒 哨点监测 

分 类 号：R512.91[医药卫生—内科学] R181.36[医药卫生—临床医学]