Recent progress of nanogenerators acting as biomedical sensors in vivo  

作　　者：Jinyan Sun Anping Yang Chaochao Zhao Fang Liu Zhou Li 

机构地区：[1]Department of Biomedical Engineering,School of Medical Engineering,Foshan University,Foshan 528000,China [2]Beijing Key Laboratory of Micro-Nano Energy and Sensor,Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 100083,China [3]Center on Nanoenergy Research,School of Physical Science and Technology,Guangxi University,Nanning 530004,China

出　　处：《Science Bulletin》2019年第18期1336-1347,共12页科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China (2016YFA0202703);the Scientific Research Foundation for Advanced Scholars of Foshan University (Gg07136, Gg07164);the Key Platform and Scientific Research Project of Guangdong Provincial Education Department (2018KTSCX246);the Science and Technology Planning Project of Guangdong Province (2018B030331001);the National Natural Science Foundation of China (61875015, 31571006, 81570202, and 8157037);the Beijing Natural Science Foundation (2182091);the National Youth Talent Support Program

摘　　要：Since the nanogenerator(NG) was invented in 2006, it has been successfully developed and utilized to harvest various forms of mechanical energy in vivo. The NGs promote the progress of self-powered biomedical devices. Moreover, NGs can also be used as sensors to detect a variety of important physiological signals, which brings us closer to real-time, high-fidelity monitoring of physical and pathological information. This paper summarizes the in vivo applications of NGs as biomedical sensors, including in cardiac sensors, respiration sensors, blood pressure sensors, gastrointestinal sensors and bladder sensors.However, there are still many challenges in using NGs as sensors in vivo. For example, how can we minimize and encapsulate the NGs, how can we increase the stability and reliability during long-term detection, and how can we establish a corresponding relationship between the NG’s electrical output and the physiological signals. It is also critical to follow the medical principles more closely in the development of self-powered sensors in the future. We believe that the self-powered sensors would promote the development of the next-generation healthcare monitoring systems.Since the nanogenerator(NG) was invented in 2006, it has been successfully developed and utilized to harvest various forms of mechanical energy in vivo. The NGs promote the progress of self-powered biomedical devices. Moreover, NGs can also be used as sensors to detect a variety of important physiological signals, which brings us closer to real-time, high-fidelity monitoring of physical and pathological information. This paper summarizes the in vivo applications of NGs as biomedical sensors, including in cardiac sensors, respiration sensors, blood pressure sensors, gastrointestinal sensors and bladder sensors.However, there are still many challenges in using NGs as sensors in vivo. For example, how can we minimize and encapsulate the NGs, how can we increase the stability and reliability during long-term detection, and how can we establish a corresponding relationship between the NG’s electrical output and the physiological signals. It is also critical to follow the medical principles more closely in the development of self-powered sensors in the future. We believe that the self-powered sensors would promote the development of the next-generation healthcare monitoring systems.

关 键 词：NANOGENERATOR IMPLANTABLE device BIOMEDICAL sensor In VIVO 

分 类 号：TP2[自动化与计算机技术—检测技术与自动化装置]