活动性葡萄膜炎引起暂时性屈光度变化（英文）  

Active uveitis induces transient refractive error changes

作　　者：Mahsa Zameni Homayoun Nikkhah Safa Rahmani Alireza Ramezani Mehdi Yaseri Masoud Soheilian Mahsa Zameni;Homayoun Nikkhah;Safa Rahmani;Alireza Ramezani;Mehdi Yaseri;Masoud Soheilian(Ophthalmic Research Center,Labbafinejad Medical Center,School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran 1666673111,Iran;Department of Ophthalmology,Torfeh Hospital,Shahid Beheshti University of Medical Sciences,Tehran 1149847514,Iran;Department of Ophthalmology,Massachusetts Eye and Ear Infirmary,Harvard Medical University,Boston 60611,United States;Ophthalmic Epidemiology Research Center,Shahid Beheshti University of Medical Sciences,Tehran 1666673111,Iran;Department of Epidemiology and Biostatics,School of Public Health,Tehran University of Medical Sciences,Tehran 147613151,Iran;Negah Eye Hospital,Tehran 1544914599,Iran)

机构地区：[1]Shahid Beheshti医科大学,Labbafinejad医疗中心,眼科研究中心,伊朗德黑兰1666673111 [2]Shahid Beheshti医科大学Torfeh医院眼科,伊朗德黑兰1149847514 [3]哈佛医学院,Massachusetts眼耳医院眼科,美国波士顿60611 [4]Shahid Beheshti医科大学眼科流行病研究中心,伊朗德黑兰1666673111 [5]德黑兰医科大学公共卫生学院流行病学与生物统计学系,伊朗德黑兰1417613151 [6]Negah眼科医院,伊朗德黑兰1544914599

出　　处：《国际眼科杂志》2019年第10期1637-1642,共6页International Eye Science

摘　　要：目的:评估活动性葡萄膜炎对屈光不正变化的影响。方法:这是一项前瞻性队列研究,纳入66例88眼活动性葡萄膜炎患者。受试者根据其疾病活动的解剖位置分为前、中、后和全葡萄膜炎。在活动期和静止期均行睫状肌麻痹验光,并对结果进行比较。结果:活动性前非肉芽肿性葡萄膜炎的球镜变化导致平均-0.25(0.77)D(95%CI:-0.5~0)的近视转变(P=0.039),在活动性中层葡萄膜炎中,平均+0.39(0.8)D(95%CI:0.09~0.69)的远视转变(P=0.003)。活动性中层葡萄膜炎的等效球镜的变化导致远视转变[+0.43(0.94)D,95%CI:0.08~0.79,P=0.005]。柱镜仅在全色素膜炎时有明显改变[-0.3(0.39)D,95%CI:-0.58^-0.02,P=0.043]。在多元分析中,我们发现疾病活动过程(急性与复发)和疾病活动的解剖位置对等效球镜变化具有统计学意义(分别为P=0.003和P=0.004)结论:活动性葡萄膜炎对屈光度有重要影响,该变化取决于具体的炎症发生部位。AIM:To evaluate the impact of active uveitis on refractive error changes.METHODS:A prospective cohort study was conducted on 66 patients(88 eyes)with active uveitis.The subjects were classified based on the anatomical location of their disease activity as anterior,intermediate,posterior and pan-uveitis.Cycloplegic refraction was performed in both active and quiescent phases,and the results were compared.RESULTS:Spherical changes in active anterior non-granulomatous uveitis resulted in an average of-0.25(0.77)D(95%CI:-0.5 to 0)shift toward myopia(P=0.039)and in active intermediate uveitis,an average of+0.39(0.8)D(95%CI:0.09-0.69)shift toward hyperopia(P=0.003).Spherical equivalent changes in active intermediate uveitis resulted in hyperopic shift[+0.43(0.94)D,95%CI:0.08-0.79,P=0.005].Cylinder had only significant changes in pan-uveitis[-0.3(0.39)D,95%CI:-0.58 to-0.02,P=0.043].In multivariate analysis,we noted that course of disease activity(acute versus recurrent)and anatomical location of disease activity had statistically significant effects on spherical equivalent changes(P=0.003 and P=0.004,respectively).CONCLUSION:Active uveitis has a significant effect on the refractive status of the eye,the changes of which depend on the inflamed anatomical area.

关 键 词：前葡萄膜炎 中间葡萄膜炎 后葡萄膜炎 全葡萄膜炎 屈光不正 

分 类 号：S66[农业科学—果树学]