青光眼滤过术后瘢痕形成机制及抗瘢痕化研究进展  

Mechanisms of scar formation and research progress in anti-fibrosis therapy after glaucoma filtration surgery

作　　者：孔亚男 陆宏[1] 陈颖[1] 李娜 刘星星 Ya-Nan Kong;Hong Lu;Ying Chen;Na Li;Xing-Xing Liu(Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学附属医院眼科

出　　处：《国际眼科杂志》2019年第10期1688-1691,共4页International Eye Science

基　　金：江苏省自然科学基金资助项目(No.BK20161287)~~

摘　　要：青光眼滤过性手术失败最主要的原因是瘢痕化造成的滤过通道堵塞。增生的瘢痕中,Tenon囊成纤维细胞转化为肌成纤维细胞持续存在,并且分泌大量的细胞外基质,胶原纤维排列紊乱。国内外学者对青光眼滤过性手术后抗瘢痕治疗进行了大量的研究,现将青光眼滤过手术后瘢痕形成机制及对应的研究进展进行综述。Filtering channels carring and subsequent obstruction are the main cause of operation failure after glaucoma filtration surgery.During the process of scarring,human Tenon fibroblasts are transformed into myofibroblasts and secrete a large amount of extracellular matrixproteins.The derangement of the collagen fiber is also observed.A large number of studies have been carried out by domestic and foreign researchers on the treatment of postoperative filtering channel scarring.In this review we summarize the mechanisms of scar formation after glaucoma filtration surgery and corresponding research progress in recent years.

关 键 词：青光眼滤过手术 滤过通道 抗瘢痕治疗 

分 类 号：R47[医药卫生—护理学]