自体穿透性角膜移植治疗角膜盲的临床观察  

Clinical observation of autologous penetrating keratoplasty in the treatment of corneal blindness

作　　者：郝兆芹[1] 高伟[1] 马强[1] 宋金鑫[1] 王小东[1] Zhao-Qin Hao;Wei Gao;Qiang Ma;Jin-Xin Song;Xiao-Dong Wang(Department of Ophthalmology,Xi'an No.1 Hospital,Xi'an 710002,Shaanxi Province,China)

机构地区：[1]中国陕西省西安市第一医院眼科

出　　处：《国际眼科杂志》2019年第10期1753-1756,共4页International Eye Science

基　　金：西安市科技计划项目[No.SF1207(1)];西安市科技计划项目[No.2017116SF/YX010(7)]~~

摘　　要：目的:观察自体穿透性角膜移植手术治疗角膜盲的临床效果。方法:采用回顾性分析,选择2014-01/2018-03行自体穿透性角膜移植治疗的患者8例8眼(角膜盲),随访1a,观察术中并发症、术后视力、术后角膜透明度和术后并发症等。结果:术后1wk时8眼患者术后裸眼视力均>0.02,复明率100%;术后1mo时5眼患者矫正视力超过0.3,3眼患者因术前白内障影响术后矫正,视力提高到0.08~0.2;术后1a,8眼患者原角膜盲眼植片均透明,无感染复发或继发感染情况发生。结论:自体角膜移植手术后角膜植片易于生长,无排斥反应,术后并发症较少,且治疗花费少,既可为单眼失明合并角膜盲的患者提供长期的有用视力,又可减轻其经济负担,为患者带来巨大利益。AIM:To investigate the clinical effect of autologous penetrating keratoplasty in the treatment of corneal blindness.METHODS:Totally 8 patients with corneal blindness were treated by autologous penetrating keratoplasty in our hospital from 2014-01 to 2018-03.Using retrospective analysis,the patients were followed up for one year.To observe the intraoperative complications and postoperative conditions such as visual acuity,corneal transparency,and other were observed.RESULTS:The uncorrected visual acuity of all the 8 patients was greater than 0.02 1wk after operation,and the rate of restoration of visual acuity was 100%(8/8).The corrected visual acuity of 5 patients(5-8)was more than 0.3 1mo after operation.The corrected visual acuity of 3 patients(3-8)with severe cataract before operation was improved to 0.08-0.2.One year later,all the corneal grafts in the recipient eyes were transparency and no recurrence of infection or secondary infection occurred in all 8 patients.CONCLUSION:Corneal graft is easy to grow and there are no exclusion reactions,fewer postoperative complications after autologous corneal transplantation.So,corneal implants can remain transparent for a long time,and the surgery cost is lower.Autologous corneal transplantation can not only provide long-term useful vision for patients with monocular blindness combined with corneal blindness,but also reduce their financial burden and bring great benefits to patients.

关 键 词：自体角膜移植 角膜盲 角膜溃疡 角膜白斑 结膜瓣遮盖 

分 类 号：R47[医药卫生—护理学]