非酒精性脂肪性肝病与中心动脉压的相关性研究  

Relationship between Non-alcoholic Fatty Liver Disease and Central Blood Pressure

作　　者：黄映芳[1] 刘毓秀 陈翠林[1] HUANG Yingfang;LIU Yuxiu;CHEN Cuilin(Department of General Medicine,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;Liver Research Center,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院全科医学科,福州350005 [2]福建医科大学附属第一医院肝病中心,福州350005

出　　处：《福建医科大学学报》2019年第4期257-260,共4页Journal of Fujian Medical University

基　　金：福建省教育厅中青年教师教育科研基金(JB12111)

摘　　要：目的探讨非酒精性脂肪性肝病(NAFLD)与中心动脉压(CAP)的相关性。方法收集患者的一般资料和血液生化指标、肝脏影像学检查、肱动脉血压及CAP检测报告,参照NAFLD诊断标准分为NAFLD组(433例)及非NAFLD组(244例),采用t检验和卡方检验比较两组资料的差别,采用二元线性Logistics回归探讨影响NAFLD的危险因素。结果与非NAFLD组比较,NAFLD组的男性、高血压病、糖尿病、吸烟、饮酒和心血管疾病(CVD)家族史例数较多,体质量指数(BMI)、甘油三酯、极低密度脂蛋白(VLDL)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ谷氨酰转肽酶(GGT)、胆碱酯酶、糖化血红蛋白、空腹血糖、尿酸、肱动脉收缩压(bSBP)、肱动脉舒张压(bDBP)、中心动脉收缩压(cSBP)、中心动脉舒张压(cDBP)显著增高(P<0.01)。糖尿病、BMI、cDBP、CVD家族史和甘油三酯与NAFLD相关(OR值分别为3.003,1.336,1.041,2.287及1.445,P<0.01)。结论NAFLD患者的cSBP和cDBP显著升高,cDBP是NAFLD的影响因素之一。Objective To investigate the relationship between nonalcoholic fatty liver disease(NAFLD)and central blood pressure.Methods This was a retrospective study.A total of 677 patients were included and they were divided into NAFLD group(n=433)and nonNALFD group(n=244).Clinical data,including age,sex,biochemical tests,liver imageological examination,brachial blood pressure and central blood pressure were collected.T test and Chisquare analysis were used to compare the variables between the two groups,and the binary linear regression was used to explore the risk factors for NAFLD.Results Compared with nonNAFLD group,the proportion of male,hypertension,diabetes,smoking,drinking and CVD family history were higher in NAFLD group,and BMI,triglyceride,VLDL,ALT,AST,GGT,cholinesterase,HbA1c,fasting bloodglucose,uric acid,bSBP,bDBP,cSBP and cDBP were significantly higher(P value<0.05)in NAFLD group.Regression showed diabetes(OR=3.003,95%CI:1.856 4.858,P<0.001),BMI(OR=1.336,95%CI:1.229 1.452,P<0.001),cDBP(OR=1.041,95%CI:1.013 1.069,P=0.004),CVD family history(OR=2.287,95%CI:1.268 4.122,P=0.006),and triglyceride(OR=1.445,95%CI:1.104 1.893,P=0.007)were risk factors of NAFLD.Conclusion The cSBP and cDBP are significantly higher in NAFLD group.cDBP is a risk factor for NAFLD.

关 键 词：非酒精性脂肪性肝病 中心动脉压 反射波 

分 类 号：R256.4[医药卫生—中医内科学] R344.2[医药卫生—中医学]